Efficient and safe methods for delivering exogenous genetic material into tissues must be
developed before the clinical potential of gene therapy will be realized. Recently, in vivo …

Lipoproteins are endogenous particles that transport lipids through the blood to various cell
types, where they are recognised and taken up via specific receptors. These particles are …

Non-viral gene-delivery systems are safer to use and easier to produce than viral vectors,
but their comparatively low transfection efficiency has limited their applications. Co-delivery …

In vivo targeted gene transfer by non‐viral vectors is subjected to anatomical constraints
depending on the route of administration. Transfection efficiency and gene expression in …

The barrier properties of the skin pose a significant but not insurmountable obstacle for
development of new effective anti-inflammatory therapies. The objective of this study was to …

The liver is an attractive target tissue for gene therapy. Current approaches for hepatic gene
delivery include retroviral and adenoviral vectors, liposome/DNA, and peptide/DNA …

Gene therapy may offer a new treatment option, particularly for patients with severe
hemophilia, based on recent research. However, individuals with pre-existing immunity to …

RNA therapeutics (eg siRNA, oligonucleotides, mRNA, etc.) show great potential for the
treatment of a myriad of diseases. However, to reach their site of action in the cytosol or …

Lipid emulsions (LEs) are heterogenous dispersions of two immiscible liquids (oil-in-water
or water-in-oil) and they are subjected to various instability processes like aggregation …

Following the initial demonstration that intramuscularly‐injected naked plasmid DNA (pDNA)
is expressed in myofibers, it was shown that pDNA can be used for vaccination purposes …