The blood–brain barrier (BBB) plays a vital role in maintaining the specialized
microenvironment of the neural tissue. It separates the peripheral circulatory system from the …

Background and Purpose—This scientific statement provides an overview of the evidence
on vascular contributions to cognitive impairment and dementia. Vascular contributions to …

Current understanding on the mechanisms of brain injury and neurodegeneration highlights
an appreciation of multicellular interactions within the neurovascular unit (NVU), which …

Astrocytes have essential roles in the central nervous system and are also implicated in the
pathogenesis of neurodegenerative disease. Forming non‐overlapping domains, astrocytes …

There is increasing evidence that cerebrovascular dysfunction plays a role not only in
vascular causes of cognitive impairment but also in Alzheimer's disease (AD). Vascular risk …

The maintenance of genomic integrity is essential for normal cellular functions. However, it is
difficult to maintain over a lifetime in postmitotic cells such as neurons, in which DNA …

Alzheimer's disease (AD) is the most common cause of dementia worldwide and is
characterised pathologically by the accumulation of amyloid beta and tau protein …

Neurodegenerative diseases are a growing health concern. The increasing incidences of
these disorders have a great impact on the patients' quality of life. Although the mechanisms …

Alzheimer's disease (AD) is the most common form of dementia in the elderly population,
affecting over 55 million people worldwide. Histopathological hallmarks of this multifactorial …

Oxidative stress has been proposed to be an important factor in the pathogenesis of
Alzheimer's disease (AD) and contributed to β-amyloid (A β) generation. Interaction between …