High-throughput methods in the discovery and study of biomaterials and materiobiology
The complex interaction of cells with biomaterials (ie, materiobiology) plays an increasingly
pivotal role in the development of novel implants, biomedical devices, and tissue …
pivotal role in the development of novel implants, biomedical devices, and tissue …
Microfluidic single-cell manipulation and analysis: Methods and applications
In a forest of a hundred thousand trees, no two leaves are alike. Similarly, no two cells in a
genetically identical group are the same. This heterogeneity at the single-cell level has been …
genetically identical group are the same. This heterogeneity at the single-cell level has been …
Profiling circulating tumour cells and other biomarkers of invasive cancers
During cancer progression, many tumours shed circulating tumour cells (CTCs) and other
biomarkers into the bloodstream. The analysis of CTCs offers the prospect of collecting a …
biomarkers into the bloodstream. The analysis of CTCs offers the prospect of collecting a …
Engineered models to parse apart the metastatic cascade
While considerable progress has been made in studying genetic and cellular aspects of
metastasis with in vitro cell culture and in vivo animal models, the driving mechanisms of …
metastasis with in vitro cell culture and in vivo animal models, the driving mechanisms of …
A review of microfluidic approaches for investigating cancer extravasation during metastasis
Metastases, or migration of cancers, are common and severe cancer complications.
Although the 5-year survival rates of primary tumors have greatly improved, those of …
Although the 5-year survival rates of primary tumors have greatly improved, those of …
Modeling the human body on microfluidic chips
Animals often fail to faithfully mimic human diseases and drug toxicities, and most in vitro
models are not complex enough to recapitulate human body function and pathophysiology …
models are not complex enough to recapitulate human body function and pathophysiology …
Recent advances in microfluidic platforms applied in cancer metastasis: Circulating tumor cells'(CTCs) isolation and tumor‐on‐a‐chip
Cancer remains the leading cause of death worldwide despite the enormous efforts that are
made in the development of cancer biology and anticancer therapeutic treatment …
made in the development of cancer biology and anticancer therapeutic treatment …
Tumor-on-a-chip for integrating a 3D tumor microenvironment: chemical and mechanical factors
L Wan, CA Neumann, PR LeDuc - Lab on a Chip, 2020 - pubs.rsc.org
Tumor progression, including metastasis, is significantly influenced by factors in the tumor
microenvironment (TME) such as mechanical force, shear stress, chemotaxis, and hypoxia …
microenvironment (TME) such as mechanical force, shear stress, chemotaxis, and hypoxia …
Multi-organs-on-chips: towards long-term biomedical investigations
Y Zhao, RK Kankala, SB Wang, AZ Chen - Molecules, 2019 - mdpi.com
With advantageous features such as minimizing the cost, time, and sample size
requirements, organ-on-a-chip (OOC) systems have garnered enormous interest from …
requirements, organ-on-a-chip (OOC) systems have garnered enormous interest from …
Microfluidic organ/body-on-a-chip devices at the convergence of biology and microengineering
Recent advances in biomedical technologies are mostly related to the convergence of
biology with microengineering. For instance, microfluidic devices are now commonly found …
biology with microengineering. For instance, microfluidic devices are now commonly found …