Regulation of myosin and filamentous actin interaction by tropomyosin is a central feature of
contractile events in muscle and nonmuscle cells. However, little is known about molecular …

Heart contraction depends on a complicated array of interactions between sarcomeric
proteins required to convert chemical energy into mechanical force. Cyclic interactions …

Hypertrophic cardiomyopathy (HCM) is the most common genetic cardiac disease. Fourteen
sarcomeric and sarcomere‐related genes have been implicated in HCM etiology, those …

Several genetic conditions can lead to left ventricular hypertrophy (LVH). Among them,
hypertrophic cardiomyopathy (HCM), caused by mutations in sarcomere genes, is the most …

Myosins are a diverse class of molecular motors responsible for movement in all eukaryotic
cells. The conversion of chemical energy from ATP hydrolysis into mechanical force …