A number of very recently developed electrochemical biosensing strategies are promoting
electrochemical biosensing systems into practical point‐of‐care applications. The focus of …

The conservation of genetic diversity has emerged as one of the central issues in
conservation biology. Although researchers in the areas of evolutionary biology, population …

We have identified a human homolog of the bacterial MutS and S. cerevisiae MSH proteins,
called hMSH2. Expression of hMSH2 in E. coli causes a dominant mutator phenotype …

By integrating an agonist satiety signal, provided by alpha–melanocyte-stimulating hormone
(α-MSH), and an antagonist signal, provided by agouti-related protein (AGRP), the …

Hereditary angioedema (HAE), a rare but life-threatening condition, manifests as acute
attacks of facial, laryngeal, genital, or peripheral swelling or abdominal pain secondary to …

A data base is described in which over 2,500 mutations in the p53 gene of human tumors
and tumor cell lines are compiled from a systematic search of reports published before 1 …

Fluorescence-based sequencing is playing an increasingly important role in efforts to
identify DNA polymorphisms and mutations of biological and medical interest. The …

Multiple endocrine neoplasia type 1 (MEN1) is an autosomal dominant disorder
characterized by tumors of the parathyroids, pancreatic islets, and anterior pituitary. The …

In paroxysmal nocturnal hemoglobinuria (PNH), acquired somatic mutations in the PIG-A
gene give rise to clonal populations of red blood cells unable to express proteins linked to …

The classification of genetic disease into chromosomal, monogenic and multifactorial
categories is an oversimplification. Phenylketonuria (PKU) is a classic …