COVID-19 has resulted in huge numbers of infections and deaths worldwide and brought
the most severe disruptions to societies and economies since the Great Depression …

The biological activity of Mannich bases, a structurally heterogeneous class of chemical
compounds that are generated from various substrates through the introduction of an …

Heterocycles form by far the largest of the classical divisions of organic chemistry. Moreover,
they are of immense importance not only both biologically and industrially but to the …

New 2-thiazolylimino-5-arylidene-4-thiazolidinones (compounds 4a–j), unsubstituted or
carrying hydroxy, methoxy, nitro and chloro groups on the benzene ring, were synthesized …

Inflammation is a natural process that is connected to various conditions and disorders such
as arthritis, psoriasis, cancer, infections, asthma, etc. Based on the fact that cyclooxygenase …

Pyrazole has been the topic of interest for thousands of researchers across the world
because of its wide spectrum pharmacological activities. Various structural modifications of …

Imidazole nucleus is a constituent of many bioactive heterocyclic compounds that are of
wide interest because of their diverse biological and clinical applications. This created …

We describe the current version of the PASS program for prediction of biological activity
spectra of organic compounds based on analysis of structure—activity relationships (SAR) …

В настоящее время преобладает направленный подходк поиску и созданиюновых
лекарств: химические соединения тестируются лишь на небольшое число требуемых …

In continuation of our study of novel quinolines with anti-inflammatory activity using the
Pfitzinger reaction, several new quinoline derivatives were synthesized and tested for their …