Its increasing incidence has led stroke to be the second leading cause of death worldwide.
Despite significant advances in recanalization strategies, patients are still at risk for …

Traumatic brain injury (TBI), particularly of greater severity (ie, moderate to severe), has
been identified as a risk factor for all-cause dementia and Parkinson's disease, with risk for …

As part of the neurovascular unit, the blood-brain barrier (BBB) is a unique, dynamic
regulatory boundary that limits and regulates the exchange of molecules, ions, and cells …

Emerging data indicate that neurological complications occur as a consequence of severe
acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. The blood–brain barrier …

Background Treatment of mild-moderate Alzheimer's disease (AD) subjects (N= 119) for 52
weeks with the SIRT1 activator resveratrol (up to 1 g by mouth twice daily) attenuates …

The pursuit of matrix metalloproteinase (MMP) inhibitors began in earnest over three
decades ago. Initial clinical trials were disappointing, resulting in a negative view of MMPs …

Numerous studies have documented increases in matrix metalloproteinases (MMPs),
specifically MMP-9 levels following stroke, with such perturbations associated with …

There is an increasing prevalence of Vascular Cognitive Impairment (VCI) worldwide, and
several studies have suggested that Chronic Cerebral Hypoperfusion (CCH) plays a critical …

The amyloid hypothesis suggests that the progressive accumulation and deposition of
central nervous system (CNS) amyloid with aging is the proximate cause of Alzheimer's …

Abstract Matrix metalloproteinase‐9 (MMP‐9) is a member of the metzincin family of mostly
extracellularly operating proteases. Despite the fact that all of these enzymes might be target …