Parkinson's disease (PD) is one of the most common and chronic degenerative diseases in
the central nervous system. The main pathology of PD formation is the progressive loss of …

Background Intestinal barrier dysfunction plays a central role in the pathological onset of
Crohn's disease. We identify the cadherin superfamily member protocadherin 20 (PCDH20) …

N-methyl-d-aspartate receptors (NMDARs) are glutamate-gated cation channels that
mediate excitatory neurotransmission and are critical for synaptic development and plasticity …

Ischemia/reperfusion caused by cardiac arrest (CA) disturbs endoplasmic reticulum (ER)
homeostasis and redox balance in neurons. AA147, originally developed as a …

Acute liver injury (ALI) and acute kidney injury (AKI) are significantly affected by the
antioxidant status. In the present study, the protective effect and mechanism of the collagen …

Suicide is a global public health concern. There is evidence of an association between
suicidal behavior and depressive disorders (DDs). An increasing number of studies have …

Numerous insults, both endogenous (eg, glutamate) and exogenous (eg, pesticides),
compromise the function of the nervous system and pose risk factors for damage or later …

The integrated stress response (ISR) comprises the eIF2α kinases PERK, GCN2, HRI, and
PKR, which induce translational and transcriptional signaling in response to diverse insults …

Imbalances in mitochondrial proteostasis are associated with pathologic mitochondrial
dysfunction implicated in etiologically diverse diseases. This has led to considerable interest …

We previously showed that the proteostasis regulator compound AA147 (N-(2-hydroxy-5-
methylphenyl) benzenepropanamide) potently protects against neurotoxic insults, such as …