Azithromycin: mechanisms of action and their relevance for clinical applications

MJ Parnham, VE Haber… - Pharmacology & …, 2014 - Elsevier
Azithromycin is a macrolide antibiotic which inhibits bacterial protein synthesis, quorum-
sensing and reduces the formation of biofilm. Accumulating effectively in cells, particularly …

Nonantimicrobial actions of macrolides: overview and perspectives for future development

JA Kricker, CP Page, FR Gardarsson… - Pharmacological …, 2021 - Elsevier
Macrolides are among the most widely prescribed broad spectrum antibacterials, particularly
for respiratory infections. It is now recognized that these drugs, in particular azithromycin …

Investigating protein–ligand interactions by solution nuclear magnetic resonance spectroscopy

W Becker, KC Bhattiprolu, N Gubensäk… - …, 2018 - Wiley Online Library
Protein–ligand interactions are of fundamental importance in almost all processes in living
organisms. The ligands comprise small molecules, drugs or biological macromolecules and …

Analytical techniques in lipidomics: state of the art

K Jurowski, K Kochan, J Walczak… - Critical Reviews in …, 2017 - Taylor & Francis
Current studies related to lipid identification and determination, or lipidomics in biological
samples, are one of the most important issues in modern bioanalytical chemistry. There are …

Photoinduced Miyaura Borylation by a Rare‐Earth‐Metal Photoreductant: The Hexachlorocerate (III) Anion

Y Qiao, Q Yang, EJ Schelter - Angewandte Chemie, 2018 - Wiley Online Library
The first photoinduced carbon (sp2)–heteroatom bond forming reaction by a rare‐earth‐
metal photoreductant, a Miyaura borylation, has been achieved. This simple, scalable, and …

[HTML][HTML] Simplifying proton NMR spectra by instant homonuclear broadband decoupling

NH Meyer, K Zangger - Angewandte Chemie (International ed. in …, 2013 - ncbi.nlm.nih.gov
NMR spectroscopy is a versatile tool to determine structural, chemical, and physical
properties of molecules. One-dimensional 1H NMR spectra probably represent the most …

14-and 15-membered lactone macrolides and their analogues and hybrids: Structure, molecular mechanism of action and biological activity

A Janas, P Przybylski - European journal of medicinal chemistry, 2019 - Elsevier
Abstract Classical macrolides containing 14-or 15-membered aglycone lactone rings are
basic and widely used antibacterial agents in clinical therapy. Macrolides exert antibacterial …

Concurrent determination of anti-microbial and anti-inflammatory drugs in lachrymal fluid and tissue by LC-MS/MS: A potential treatment for microbial keratitis and its …

A Mishra, AD Choudhury, A Biswas, V Singh… - … of Pharmaceutical and …, 2024 - Elsevier
Unforeseen surfacing of microbial keratitis (MKT) over the years has led to a requisite for
promising treatment strategy involving combination of antifungal and antibacterial agents …

[HTML][HTML] Existing highly accumulating lysosomotropic drugs with potential for repurposing to target COVID-19

U Norinder, A Tuck, K Norgren, VM Kos - Biomedicine & Pharmacotherapy, 2020 - Elsevier
Given the speed of viral infection spread, repurposing of existing drugs has been given the
highest priority in combating the ongoing COVID-19 pandemic. Only drugs that are already …

Azithromycin-Induced Changes to Bacterial Membrane Properties Monitored in Vitro by Second-Harmonic Light Scattering

M Sharifian Gh, MJ Wilhelm, HL Dai - ACS medicinal chemistry …, 2018 - ACS Publications
We present a nonlinear light scattering method for monitoring, with real-time resolution and
membrane specificity, changes in molecular adsorption, and transport at bacterial …