Nonribosomal peptide synthesis—principles and prospects
RD Süssmuth, A Mainz - Angewandte Chemie International …, 2017 - Wiley Online Library
Nonribosomal peptide synthetases (NRPSs) are large multienzyme machineries that
assemble numerous peptides with large structural and functional diversity. These peptides …
assemble numerous peptides with large structural and functional diversity. These peptides …
Structural advances toward understanding the catalytic activity and conformational dynamics of modular nonribosomal peptide synthetases
Covering: up to fall 2022. Nonribosomal peptide synthetases (NRPSs) are a family of
modular, multidomain enzymes that catalyze the biosynthesis of important peptide natural …
modular, multidomain enzymes that catalyze the biosynthesis of important peptide natural …
Structural biology of nonribosomal peptide synthetases
The nonribosomal peptide synthetases are modular enzymes that catalyze synthesis of
important peptide products from a variety of standard and non-proteinogenic amino acid …
important peptide products from a variety of standard and non-proteinogenic amino acid …
Biosynthesis of ilamycins featuring unusual building blocks and engineered production of enhanced anti-tuberculosis agents
J Ma, H Huang, Y Xie, Z Liu, J Zhao, C Zhang… - Nature …, 2017 - nature.com
Tuberculosis remains one of the world's deadliest communicable diseases, novel anti-
tuberculosis agents are urgently needed due to severe drug resistance and the co-epidemic …
tuberculosis agents are urgently needed due to severe drug resistance and the co-epidemic …
Structural, functional and evolutionary perspectives on effective re-engineering of non-ribosomal peptide synthetase assembly lines
Covering: up to May 2018 Non-ribosomal peptide synthetases (NRPSs) are mega-enzymes
that form modular templates to assemble specific peptide products, independent of the …
that form modular templates to assemble specific peptide products, independent of the …
Iron Acquisition Mechanisms and Their Role in the Virulence of Burkholderia Species
AT Butt, MS Thomas - Frontiers in cellular and infection microbiology, 2017 - frontiersin.org
Burkholderia is a genus within the β-Proteobacteriaceae that contains at least 90 validly
named species which can be found in a diverse range of environments. A number of …
named species which can be found in a diverse range of environments. A number of …
Structure of PA1221, a nonribosomal peptide synthetase containing adenylation and peptidyl carrier protein domains
Many bacteria use large modular enzymes for the synthesis of polyketide and peptide
natural products. These multidomain enzymes contain integrated carrier domains that …
natural products. These multidomain enzymes contain integrated carrier domains that …
Biosynthetic gene cluster of the non-ribosomally synthesized cyclodepsipeptide skyllamycin: deciphering unprecedented ways of unusual hydroxylation reactions
S Pohle, C Appelt, M Roux, HP Fiedler… - Journal of the …, 2011 - ACS Publications
The cyclic depsipeptide skyllamycin A is a potent inhibitor of the platelet-derived growth
factor (PDGF) signaling pathway by inhibiting binding of homodimeric PDGF BB to the PDGF …
factor (PDGF) signaling pathway by inhibiting binding of homodimeric PDGF BB to the PDGF …
Virulence mechanisms of plant-pathogenic Streptomyces species: an updated review
Y Li, J Liu, G Díaz-Cruz, Z Cheng… - Microbiology, 2019 - microbiologyresearch.org
Gram-positive Actinobacteria from the genus Streptomyces are best known for their
morphological complexity and for their ability to produce numerous bioactive specialized …
morphological complexity and for their ability to produce numerous bioactive specialized …
The structural basis of N-acyl-α-amino-β-lactone formation catalyzed by a nonribosomal peptide synthetase
DF Kreitler, EM Gemmell, JE Schaffer… - Nature …, 2019 - nature.com
Nonribosomal peptide synthetases produce diverse natural products using a multidomain
architecture where the growing peptide, attached to an integrated carrier domain, is …
architecture where the growing peptide, attached to an integrated carrier domain, is …