Foam cell formation and further accumulation in the subendothelial space of the vascular
wall is a hallmark of atherosclerotic lesions. Targeting foam cell formation in the …

The enzymes acyl-coenzyme A (CoA): cholesterol acyltransferases (ACATs) are membrane-
bound proteins that utilize long-chain fatty acyl-CoA and cholesterol as substrates to form …

Covering: up to May 2010 This review (with 335 references cited) is devoted to pentacyclic
triterpenes. The total synthesis, semi-synthesis, structural modification, and metabolic …

Obesity with associated comorbidities is currently a worldwide epidemic and among the
most challenging health conditions in the 21st century. A major metabolic consequence of …

Cardiovascular disease represents the most common cause of death in patients with
nonalcoholic fatty liver disease (NAFLD). Patients with NAFLD exhibit an atherogenic …

As members of the membrane-bound O-acyltransferase (MBOAT) enzyme family, acyl-
coenzyme A: cholesterol acyltransferases (ACATs) catalyse the transfer of an acyl group …

Hyperlipidemia is an abnormality of lipid metabolism, characterized by an elevation of total
cholesterol, triglyceride, and low density lipoprotein-cholesterol, and/or a decreasing of high …

Quinazolinones belong to a family of heterocyclic nitrogen compounds that have attracted
increasing interest because of their broad spectrum of biological functions. This review …

Sterol O-acyltransferase (SOAT) is a membrane-bound enzyme that aids the esterification of
cholesterol and fatty acids to cholesterol esters. SOAT has been studied extensively as a …

Lipid-lowering therapy is an important tool for the treatment of lipid metabolic diseases,
which are increasing in prevalence. However, the failure of conventional lipid-lowering …