Transient receptor potential (TRP) channels are multifunctional signalling molecules with
many roles in sensory perception and cellular physiology. Therefore, it is not surprising that …

Transient receptor potential (TRP) channels are sensors for a variety of cellular and
environmental signals. Mammals express a total of 28 different TRP channel proteins, which …

Myofibroblasts are the construction workers of wound healing and repair damaged tissues
by producing and organizing collagen/extracellular matrix (ECM) into scar tissue. Scar tissue …

Cardiac fibrosis is mediated by the activation of resident cardiac fibroblasts, which
differentiate into myofibroblasts in response to injury or stress. Although myofibroblast …

Diffuse myocardial fibrosis resulting from the excessive deposition of collagen fibres through
the entire myocardium is encountered in a number of chronic cardiac diseases. This lesion …

The ECM (extracellular matrix) network plays a crucial role in cardiac homeostasis, not only
by providing structural support, but also by facilitating force transmission, and by transducing …

Ferroptosis is an iron-dependent regulated cell death marked by excessive oxidative
phospholipids (PLs). The polyunsaturated fatty acids-containing phospholipids (PUFA-PLs) …

Physiological tissue repair aims at restoring the mechano-protective properties of the
extracellular matrix. Consequently, redundant regulatory mechanisms are in place ensuring …

Both type 1 and type 2 diabetes are associated with cardiac fibrosis that may reduce
myocardial compliance, contribute to the pathogenesis of heart failure, and trigger …

Myofibroblasts are activated in response to tissue injury with the primary task to repair lost or
damaged extracellular matrix. Enhanced collagen secretion and subsequent contraction …