Nucleotides are substrates for multiple anabolic pathways, most notably DNA and RNA
synthesis. Since nucleotide synthesis inhibitors began to be used for cancer therapy in the …

Tumor metabolism is emerging as a potential target for cancer therapies. This new approach
holds particular promise for the treatment of glioblastoma, a highly lethal brain tumor that is …

Glioblastoma is the most common form of primary malignant brain tumor in adults and one of
the most lethal human cancers, with high recurrence and therapy resistance. Glioblastoma …

Glioblastoma (GBM) is an aggressive and highly malignant primary brain tumor
characterized by rapid growth and a poor prognosis for patients. Despite advancements in …

Ferroptosis, a recently identified form of regulated cell death, is characterized by lipid
peroxidation and iron accumulation, plays a critical role in early brain injury after …

Malignant rhabdoid tumor (MRT) is one of the most aggressive childhood cancers for which
no effective treatment options are available. Reprogramming of cellular metabolism is an …

Clear cell renal cell carcinoma (ccRCC) is a malignant tumor of the urinary system. To
explore the potential mechanisms of DHODH in ccRCC, we analyzed its molecular …

The recurrence or resistance to treatment of primary liver cancer (PLL) is significantly related
to the heterogeneity present within the tumor. In this study, we integrated prognosis risk …

Introduction Stage III non-small cell lung cancer (NSCLC) is a composite of the regional
spread of lung cancer with different levels of potential lymph node involvement and tumor …

Objectives We aimed to determine the role of dihydroorotate dehydrogenase (DHODH) in
pathogenesis of adult T‐cell leukemia (ATL) caused by human T‐cell leukemia virus type 1 …