Ferroptosis nanomedicine: clinical challenges and opportunities for modulating tumor metabolic and immunological landscape

H Yang, X Yao, Y Liu, X Shen, M Li, Z Luo - Acs Nano, 2023 - ACS Publications
Ferroptosis, a type of regulated cell death driven by iron-dependent phospholipid
peroxidation, has captured much attention in the field of nanomedicine since it was coined in …

The crosstalk between ferroptosis and anti‐tumor immunity in the tumor microenvironment: molecular mechanisms and therapeutic controversy

Y Zheng, L Sun, J Guo, J Ma - Cancer Communications, 2023 - Wiley Online Library
The advent of immunotherapy has significantly reshaped the landscape of cancer treatment,
greatly enhancing therapeutic outcomes for multiple types of cancer. However, only a small …

A MOF-based potent ferroptosis inducer for enhanced radiotherapy of triple negative breast cancer

L Zeng, S Ding, Y Cao, C Li, B Zhao, Z Ma, J Zhou… - ACS …, 2023 - ACS Publications
Radiotherapy (RT) is one of the important clinical treatments for local control of triple-
negative breast cancer (TNBC), but radioresistance still exists. Ferroptosis has been …

Ultrathin Clay Nanoparticles‐Mediated Mutual Reinforcement of Ferroptosis and Cancer Immunotherapy

J Liu, J Zhan, Y Zhang, L Huang, J Yang… - Advanced …, 2024 - Wiley Online Library
Ferroptosis‐triggered immunogenic cell death (ICD) is widely adopted to potentiate the
body's antitumor immunity by catalyzing the production of toxic reactive oxygen species …

All-in-one engineering multifunctional nanoplatforms for sensitizing tumor low-temperature photothermal therapy in vivo

K Li, K Xu, S Liu, Y He, M Tan, Y Mao, Y Yang, J Wu… - ACS …, 2023 - ACS Publications
Low-temperature photothermal therapy (PTT) is a noninvasive method that harnesses the
photothermal effect at low temperatures to selectively eliminate tumor cells, while …

Copper‐Based Composites Nanoparticles Improve Triple‐Negative Breast Cancer Treatment With Induction of Apoptosis‐Cuproptosis and Immune Activation

N Wang, Y Liu, D Peng, Q Zhang… - Advanced …, 2024 - Wiley Online Library
The synergistic effect of apoptosis and cuproptosis, along with the activation of the immune
system, presents a promising approach to enhance the efficacy against triple‐negative …

Asymmetric Coordination of Iron Single‐Atom Nanozymes with Efficient Self‐Cascade Catalysis for Ferroptosis Therapy

W Liu, Q Chen, J Wu, F Zhang, L Han… - Advanced Functional …, 2024 - Wiley Online Library
Single‐atom nanozymes (SAzymes) hold great promise in tumor therapy due to their
maximized atomic utilization and well‐defined electronic structures. However, they still face …

The roles of ferroptosis in cancer: tumor suppression, tumor microenvironment, and therapeutic interventions

G Lei, L Zhuang, B Gan - Cancer cell, 2024 - cell.com
In cancer treatment, the recurrent challenge of inducing apoptosis through conventional
therapeutic modalities, often thwarted by therapy resistance, emphasizes the critical need to …

Copper homeostasis and cuproptosis in tumor pathogenesis and therapeutic strategies

C Bian, Z Zheng, J Su, S Chang, H Yu, J Bao… - Frontiers in …, 2023 - frontiersin.org
Copper is an indispensable micronutrient for the development and replication of all
eukaryotes, and its redox properties are both harmful and beneficial to cells. An imbalance …

Multifunctional tumor-targeting Carbon dots for Tumor Microenvironment activated ferroptosis and immunotherapy in Cancer Treatment

Y Bao, G Li, S Li, H Zhang, X Wu, R Yan… - … applied materials & …, 2023 - ACS Publications
As an emerging cancer treatment strategy, ferroptosis is distinguished by the perturbation of
lipid metabolism equilibrium and the accumulation of lipid peroxidation. However, the …