The nicotinamide/streptozotocin rodent model of type 2 diabetes: Renal pathophysiology and redox imbalance features

LJ Yan - Biomolecules, 2022 - mdpi.com
Diabetic nephropathy (DN) is a common complication of diabetes mellitus. While there has
been a great advance in our understanding of the pathogenesis of DN, no effective …

Regulation of carbohydrate metabolism by nitric oxide and hydrogen sulfide: Implications in diabetes

S Gheibi, AP Samsonov, S Gheibi, AB Vazquez… - Biochemical …, 2020 - Elsevier
Nitric oxide (NO) and hydrogen sulfide (H 2 S) are two gasotransmitters that are produced in
the human body and have a key role in many of the physiological activities of the various …

[HTML][HTML] Insulin secretion: The nitric oxide controversy

S Gheibi, A Ghasemi - EXCLI journal, 2020 - ncbi.nlm.nih.gov
Nitric oxide (NO) is a gas that serves as a ubiquitous signaling molecule participating in
physiological activities of various organ systems. Nitric oxide is produced in the endocrine …

Interaction among hydrogen sulfide and other gasotransmitters in mammalian physiology and pathophysiology

YQ Huang, HF Jin, H Zhang, CS Tang… - Advances in Hydrogen …, 2021 - Springer
Abstract Hydrogen sulfide (H 2 S), nitric oxide (NO), carbon monoxide (CO), and sulfur
dioxide (SO 2) were previously considered as toxic gases, but now they are found to be …

Lost-in-translation of metabolic effects of inorganic nitrate in type 2 diabetes: is ascorbic acid the answer?

Z Bahadoran, P Mirmiran, K Kashfi… - International Journal of …, 2021 - mdpi.com
Beneficial metabolic effects of inorganic nitrate (NO3−) and nitrite (NO2−) in type 2 diabetes
mellitus (T2DM) have been documented in animal experiments; however, this is not the case …

Anti‐obesity effects of Beta vulgaris and Eruca sativa‐based extracts

M Markou, A Katsouda, V Papaioannou… - Phytotherapy …, 2024 - Wiley Online Library
Obesity is a major source of morbidity worldwide with more than 2 billion adults being
overweight or obese. The incidence of obesity has tripled in the last 50 years, leading to an …

Long-term nitrate administration increases expression of browning genes in epididymal adipose tissue of male type 2 diabetic rats

S Jeddi, N Yousefzadeh, H Afzali, A Ghasemi - Gene, 2021 - Elsevier
Expression of browning genes are lower in both humans and animals with type 2 diabetes
(T2D). This study aims at determining effects of long-term nitrate administration on protein …

Effect of inorganic nitrate on metabolic parameters in patients with type 2 diabetes: A 24-week randomized double-blind placebo-controlled clinical trial

Z Bahadoran, R Norouzirad, P Mirmiran, Z Gaeini… - Nitric Oxide, 2021 - Elsevier
Aim In this randomized placebo-controlled clinical trial, effect of oral inorganic nitrate (NO
3−) on metabolic parameters was assessed in patients with type 2 diabetes mellitus (T2DM) …

Hydrogen sulfide plays a potential alternative for the treatment of metabolic disorders of diabetic cardiomyopathy

NH Deng, W Luo, DD Gui, BJ Yan, K Zhou… - Molecular and Cellular …, 2022 - Springer
Diabetic cardiomyopathy (DCM) is a cardiovascular complication that tends to occur in
patients with diabetes, obesity, or insulin resistance, with a higher late mortality rate …

Sodium hydrosulfide has no additive effects on nitrite-inhibited renal gluconeogenesis in type 2 diabetic rats

S Jeddi, S Gheibi, K Kashfi, A Ghasemi - Life Sciences, 2021 - Elsevier
Objective Increased renal and hepatic gluconeogenesis are important sources of fasting
hyperglycemia in type 2 diabetes (T2D). The inhibitory effect of co-administration of sodium …