Aminoacyl-tRNA synthetases (ARSs) play a vital role in protein synthesis by linking amino
acids to their cognate transfer RNAs (tRNAs). This typical function has been well recognized …

Antisynthetase syndrome (ASSD) is an autoimmune disease characterized by circulating
autoantibodies against one of eight aminoacyl-tRNA synthetases (aaRSs). Although these …

Analyzing host cells' transcriptional response to severe acute respiratory syndrome
coronavirus 2 (SARS-CoV-2) infection will help delineate biological processes underlying …

SARS-CoV-2-associated acute respiratory distress syndrome (ARDS) and acute lung injury
are life-threatening manifestations of severe viral infection. The pathogenic mechanisms that …

Abstract Background and Aim Metabolic reprogramming is characterized by dysregulated
levels of metabolites and metabolic enzymes. Integrated metabolomic and transcriptomic …

Background Uveal melanoma (UM) is the most common primary intraocular malignancy in
adults. Many previous studies have demonstrated that the infiltrating of immune and stromal …

While cytoplasmic tryptophanyl-tRNA synthetase (WARS1) ligates tryptophan (Trp) to its
cognate tRNAs for protein synthesis, it also plays a role as an innate immune activator in …

Extracellular vesicles (EVs) are biomolecule carriers for intercellular communication in
health and disease. Nef is a HIV virulence factor that is released from cells within EVs and is …

Despite intensive clinical and scientific efforts, the mortality rate of sepsis remains high due
to the lack of precise biomarkers for patient stratification and therapeutic guidance. Secreted …

Abstract Ethnopharmacological relevance Hedyotis diffusa Willd, also named Scleromitrion
diffusum (Willd.) RJ Wang, is one medical herb, which has been traditionally used by the …