Metaiodobenzylguanidine(MIBG) was developed 18 yr ago for scintigraphic imaging of the
adrenomedullary tumors pheochromocytoma and neuroblastoma. Many studies have shown …

The increasing amount of clinically relevant information obtained by positron emission
tomography (PET), primarily with fluorine-18 labelled 2-deoxy-2-fluoro-d-glucose, has …

Planar Imaging Protocol. All sympathomimetic medicines that could potentially interfere with
the uptake ofMIBG were discontin ued for at least 5 half-lives before the scintigraphic …

The autonomic nervous system plays a critical role in the regulation of cardiac function.
Abnormalities of cardiac innervation have been implicated in the pathophysiology of many …

The human cardiac nervous system consists of a sympathetic and a parasympathetic branch
with (–)-norepinephrine and acetylcholine as the respective endogenous neurotransmitters …

The halogens bromine and iodine have similar chemical properties and undergo similar
reactions due to their closeness in Group 17 of the periodic chart. There are a number of …

Since the introduction of radioiodinated m-iodobenzylguanidine in 1980, much research has
been performed, both in the chemical field as well as in medical sciences. This paper …

The aims of this investigation were to develop a no-carrier-added (nca) synthesis of (4-[18F]-
fluoro-3-iodobenzyl) guanidine ([18F] FIBG) and to evaluate its potential as an MIBG …

Abstract [76 Br]-meta-Bromobenzylguanidine ([76 Br] MBBG) was prepared from the
iodinated analog (MIBG) and [76 Br] NH 4 using a Cu+-assisted halogen exchange …

Fluorine-18-(t1/2 109.8 min) and carbon-11 (t1/2 20.4 min)-labeled norepinephrine
analogues have been found previously to be useful positron-emission-tomography (PET) …