The current review and synthesis serves to define and contextualize fear of the unknown
relative to related constructs, such as intolerance of uncertainty, and contemporary models …

The current review and synthesis was designed to provocatively develop and evaluate the
proposition that “fear of the unknown may be a, or possibly the, fundamental fear”(Carleton …

Data will be reviewed using the acoustic startle reflex in rats and humans based on our
attempts to operationally define fear vs anxiety. Although the symptoms of fear and anxiety …

The intimate connection between the brain and the heart was enunciated by Claude
Bernard over 150 years ago. In our neurovisceral integration model we have tried to build on …

Rationale Preclinical data indicates that threat stimuli elicit two classes of defensive
behaviors, those that are associated with imminent danger and are characterized by flight or …

Background: Although traditional forms of therapy for anxiety-related disorders (eg, cognitive
behavioral therapy, CBT) have been effective, there have been long-standing issues with …

Background Consumer-available virtual-reality technology was launched in 2016 with
strong foundations in the entertainment-industry. We developed an innovative medical …

Using the Iowa Gambling Task (IGT) and psychophysiological correlates of emotional
responses (ie, heart rate and skin conductance), we investigate the effects of trait anxiety …

Understanding schizophrenia requires consideration of patients' interactions in the social
world. Misinterpretation of other peoples' behavior is a key feature of persecutory ideation …

Aberrant subcortical–prefrontal connectivity may contribute to insula hyper-reactivity to threat
in generalized social anxiety disorder (gSAD). A novel PsychoPhysiological Interaction (PPI) …