No other tissue in the body depends more on the composition and organization of the
extracellular matrix (ECM) for normal structure and function than the corneal stroma. The …

Ageing of human skin may result from both the passage of time (intrinsic ageing) and from
cumulative exposure to external influences (extrinsic ageing) such as ultraviolet radiation …

The extracellular matrix (ECM) of blood vessels, which is composed of both the vascular
basement membrane (BM) and the interstitial ECM is identified as a crucial component of …

Adipocytes represent a major cell type in the mammary tumor microenvironment and are
important for tumor growth. Collagen VI (COL6) is highly expressed in adipose tissue …

Background: Idiopathic epiretinal membrane (iERM) is a fibrocellular membrane that
proliferates on the inner surface of the retina at the macular area. Membrane contraction is …

Systemic light chain (LC) amyloidosis (AL) is a disease where organs are damaged by an
overload of a misfolded patient-specific antibody-derived LC, secreted by an abnormal B cell …

The extracellular matrix (ECM) of the trabecular meshwork (TM) is thought to be important in
regulating intraocular pressure (IOP) in both normal and glaucomatous eyes. IOP is …

The basic building block of the extra-cellular matrix in native tissue is collagen. As a
structural protein, collagen has an inherent biocompatibility making it an ideal material for …

Laminin (Ln) and collagen are multifunctional glycoproteins that play an important role in
cellular morphogenesis, cell signalling, tissue repair and cell migration. These proteins are …

The collagen VI-related myopathy known as Ullrich congenital muscular dystrophy is an
early-onset disease that combines substantial muscle weakness with striking joint laxity and …