Since its' discovery over 20 years ago, BDNF has been shown to play a key role in neuronal
survival, in promoting neuronal regeneration following injury, regulating transmitter systems …

Stressors ranging from psychogenic/social to neurogenic/injury to systemic/microbial can
impact microglial inflammatory processes, but less is known regarding their effects on …

Myelination is essential for rapid impulse conduction in the CNS, but what determines
whether an individual axon becomes myelinated remains unknown. Here we show, using a …

purpose. In both animal model systems and in human glaucoma, retinal ganglion cells
(RGCs) die by apoptosis. To understand how RGC apoptosis is initiated in these systems …

Functional loss after spinal cord injury (SCI) is caused, in part, by demyelination of axons
surviving the trauma. Neurotrophins have been shown to induce oligodendrogliagenesis in …

Apoptosis or programmed cell death has been reported after CNS trauma. However, the
significance of this mechanism in the pathophysiology of spinal cord injury, in particular at …

Neurotrophins (NTs) promote neuronal survival and maintenance during development and
after injury. However, their role in the communication between the nervous system and the …

Background Transplantation of embryonic stem or neural progenitor cells is an attractive
strategy for repair of the injured central nervous system. Transplantation of these cells alone …

To promote axonal regeneration in the injured adult spinal cord, a two‐phase repair strategy
was employed to (i) bridge a spinal cord hemilesion cavity with a grafted Schwann cell (SC) …

Previous work in culture has shown that basal forebrain (BF) oligodendrocyte (OLG) lineage
cells respond to BDNF by increasing DNA synthesis and differentiation. Further, in the BF in …