Sensory transduction in auditory hair cells—PIEZOs can’t touch this | Journal of General
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Calcium and integrin-binding protein 2 (CIB2) and CIB3 bind to transmembrane channel-like
1 (TMC1) and TMC2, the pore-forming subunits of the inner-ear mechano-electrical …

Hair cell bundles consist of stereocilia arranged in rows of increasing heights, connected by
tip links that transmit sound-induced forces to shorter stereocilia tips. Auditory …

The etiology of hearing impairment is multifactorial, with contributions from both genetic and
environmental factors. Although genetic studies have yielded valuable insights into the …

During auditory transduction, sound-evoked vibrations of the hair cell stereociliary bundles
open mechanotransducer (MET) ion channels via tip links extending from one stereocilium …

Transmembrane channel-like (TMC) proteins are expressed throughout the animal kingdom
and are thought to encode components of ion channels. Mammals express eight TMCs …

TMC1, a unique causative gene associated with deafness, exhibits variants with autosomal
dominant and recessive inheritance patterns. TMC1 codes for the transmembrane channel …

Mechanical force controls the opening and closing of mechanosensitive ion channels atop
the hair bundles of the inner ear. The filamentous tip link connecting transduction channels …

Hearing is initiated in hair cells by the mechanical activation of ion channels in the hair
bundle. The hair bundle is formed by stereocilia organized into rows of increasing heights …

Hearing and balance rely on the conversion of a mechanical stimulus into an electrical
signal, a process known as mechanosensory transduction (MT). In vertebrates, this process …