Apo2 ligand or tumour necrosis factor-related apoptosis-inducing ligand (Apo2L/TRAIL) is
one of the several members of the tumour necrosis factor (TNF) gene superfamily that …

Apo2 ligand or tumor necrosis factor (TNF)-related apoptosis-inducing ligand (Apo2L/TRAIL)
is one of several members of the TNF gene superfamily that induce apoptosis through …

Activation of the transcription factor NF-κB is a major effector of the inducible resistance to
death receptor-mediated apoptosis. Previous evidence indicates that the combined …

The caspase 8 homologue FLICE-inhibitory protein (cFLIP) is a potent negative regulator of
death receptor-induced apoptosis. We found that cFLIP can be upregulated in some cell …

Death receptor-or mitochondrion-dependent apoptosis is initiated by the recruitment and
activation of apical caspases in the apoptosis signaling pathways. In death receptor …

Apoptosis plays a critical role in lymphocyte development and homeostasis. Enhanced
lymphocyte apoptosis can cause immunodeficiency through cell loss. Conversely, inhibition …

Upon stimulation, CD95 (APO-1/Fas) recruits the adapter molecule FADD/MORT1,
procaspase-8, and the cellular FLICE-inhibitory proteins (c-FLIP) into the death-inducing …

Cell death is executed along several pathways. Apart from necrotic cell death occurring
upon tissue injury, several distinct types of apoptosis have been observed. Apoptosis, or …

A role for caspase-10, previously implicated in the autoimmune lymphoproliferative
syndrome, in death receptor signaling has not been directly shown. Here we show that …

Apoptotic cell death plays a critical role in the development and functioning of the immune
system. During differentiation, apoptosis weeds out lymphocytes lacking useful antigen …