The fast-growing body of experimental data on metalloenzymes and organometallic
compounds is fostering the exploitation of metal–ligand interactions for the design of new …

Repair of DNA double-strand breaks (DSB) is performed by two major pathways, homology-
dependent repair and classical nonhomologous end-joining. Recent studies have identified …

Mitochondrial DNA (mtDNA) escaping stressed mitochondria provokes inflammation via
cGAS-STING pathway activation and, when oxidized (Ox-mtDNA), it binds cytosolic NLRP3 …

Poly (ADP-ribose) is synthesized by PARP enzymes during the repair of stochastic DNA
breaks. Surprisingly, however, we show that most if not all endogenous poly (ADP-ribose) is …

Poor survival rates of patients with tumors arising from or disseminating into the brain are
attributed to an inability to excise all tumor tissue (if operable), a lack of blood-brain barrier …

BRCA1 or BRCA2 inactivation drives breast and ovarian cancer but also creates
vulnerability to poly (ADP-ribose) polymerase (PARP) inhibitors. To search for additional …

Lung cancer is one of the leading causes of cancer mortality worldwide. The therapeutic
effect of chemotherapy is limited due to the resistance of cancer cells, which remains a …

The SARS-CoV-2 coronavirus is the causal agent of the current global pandemic. SARS-
CoV-2 belongs to an order, Nidovirale s, with very large RNA genomes. It is proposed that …

Synthetic lethality strategies for cancer therapy exploit cancer-specific genetic defects to
identify targets that are uniquely essential to the survival of tumor cells. Here we show …

DNA replication and repair enzyme Flap Endonuclease 1 (FEN1) is vital for genome
integrity, and FEN1 mutations arise in multiple cancers. FEN1 precisely cleaves single …