Tumors have evolved in various mechanisms to evade the immune system, hindering the
antitumor immune response and facilitating tumor progression. Immunotherapy has become …

Regulation of ubiquitination is involved in various processes in cancer occurrence and
development, including cell cycle arrest, cell proliferation, apoptosis, invasion, metastasis …

Chronic stress–induced epinephrine (EPI) accelerates breast cancer progression and
metastasis, but the molecular mechanisms remain unclear. Herein, we found a strong …

Hepatocellular carcinoma (HCC) is a common solid tumor with high rate of recurrence and
mortality. Anti-angiogenesis drugs have been used for the therapy of HCC. However, anti …

Ubiquitination refers to the conjugation of the ubiquitin protein (a small protein highly
conserved among eukaryotes) to itself or to other proteins through differential use of …

Recently, many studies have shown that deubiquitination modification of proteins is of great
significance in major physiological processes such as cell proliferation, apoptosis, and …

Eukaryotic cells are constantly exposed to both endogenous and exogenous stressors that
promote the induction of DNA damage. Of this damage, double strand breaks (DSBs) are the …

The ubiquitin-specific peptidase Ataxin-3 (ATXN3) has emerged as a potential oncogene in
a variety of human cancers. However, the molecular mechanisms underlying how ATXN3 …

Summary N 6-methyladenosine (m 6 A) methyltransferase Mettl3 is involved in conventional
T cell immunity; however, its role in innate immune cells remains largely unknown. Here, we …

Monoubiquitination is a post-translational modification (PTM), through which a single
ubiquitin molecule is covalently conjugated to a lysine residue of the target protein …