Mutation is the engine that drives evolution and adaptation forward in that it generates the
variation on which natural selection acts. Mutation is a random process that nevertheless …

The correlation between genomic G+ C content and optimal growth temperature in
prokaryotes has gained renewed interest after Musto et al.[H. Musto, H. Naya, A. Zavala, H …

Background GC pairs are generally more stable than AT pairs; GC-rich genomes were
proposed to be more adapted to high temperatures than AT-rich genomes. Previous studies …

Two years ago, we showed that positive correlations between optimal growth temperature
(Topt) and genome GC are observed in 15 out of the 20 families of prokaryotes we analyzed …

For a long time, the central issue of evolutionary genomics was to find out the adaptive
strategy of nucleic acid molecules of various microorganisms having different optimal growth …

Background The environment has been playing an instrumental role in shaping and
maintaining the morphological, physiological and biochemical diversities of prokaryotes. It …

Background Among the four bases, guanine is the most susceptible to damage from
oxidative stress. Replication of DNA containing damaged guanines results in G to T …

Weak triplet codon–anticodon interactions render ribosome-free translation unlikely. Some
modern tRNAs read quadruplet codons (tetracodons), suggesting vestigial ribosome-free …

The relationship between codon usage in prokaryotes and their ability to grow at extreme
temperatures has been given much attention over the past years. Previous studies have …

Eubacterial genomes have highly variable GC content (0.17–0.75) and the primary
mechanism of such variability remains unknown. The place to look for is what actually …