Once focused mainly on the characterization of neoplasms, immunohistochemistry (IHC)
today is used in the investigation of a broad range of disease processes with applications in …

As targeted molecular therapies and immuno-oncology have become pivotal in the
management of patients with lung cancer, the essential requirement for high throughput …

Although patients with microsatellite instable metastatic colorectal cancer (CRC) benefit from
immune checkpoint blockade, chemotherapy with targeted therapies remains the only …

Objectives The interaction between the immune system and tumor cells is an important
feature for the prognosis and treatment of cancer. Multiplex immunohistochemistry (mIHC) …

Immunohistochemistry (IHC) is a tool for visualizing protein expression that is employed as
part of the diagnostic workup for the majority of solid tissue malignancies. Existing IHC …

Single-cell analysis reveals aspects of cellular physiology not evident from population-
based studies, particularly in the case of highly multiplexed methods such as mass …

Limitations on the number of unique protein and DNA molecules that can be characterized
microscopically in a single tissue specimen impede advances in understanding the …

Objective Melanopsin retinal ganglion cells (mRGCs) are photoreceptors driving circadian
photoentrainment, and circadian dysfunction characterizes Alzheimer disease (AD). We …

Background & Aims Changes to the microenvironment of pancreatic ductal
adenocarcinomas (PDACs) have been associated with poor outcomes of patients. We …

Understanding the role of factors that regulate intestinal epithelial homeostasis and
response to injury and regeneration is important. The current literature describes several …