The process of poly (ADP-ribosyl) ation and the major enzyme that catalyses this reaction,
poly (ADP-ribose) polymerase 1 (PARP1), were discovered more than 50 years ago. Since …

The eukaryotic cell is a bustling collection of macromolecules acting cooperatively to
mediate the functions required for cell viability. Specific, context-dependent and tightly …

In amyotrophic lateral sclerosis (ALS) and frontotemporal degeneration (FTD), cytoplasmic
aggregates of hyperphosphorylated TDP-43 accumulate and colocalize with some stress …

The stability of the Wnt pathway transcription factor β-catenin is tightly regulated by the multi-
subunit destruction complex. Deregulated Wnt pathway activity has been implicated in many …

Posttranslational modifications (PTMs) regulate protein functions and interactions. ADP-
ribosylation is a PTM, in which ADP-ribosyltransferases use nicotinamide adenine …

Recent findings have thrust poly (ADP-ribose) polymerases (PARPs) into the limelight as
potential chemotherapeutic targets. To provide a framework for understanding these recent …

Wnt/β-Catenin signaling plays key roles in tissue homeostasis and cell fate decisions in
embryonic and post-embryonic development across the animal kingdom. As a result …

Poly (ADP-ribose) is a posttranslational modification and signaling molecule that regulates
many aspects of human cell biology, and it is synthesized by enzymes known as poly (ADP …

Aberrant activation of the Wnt/β‐catenin signaling circuit is associated with cancer
recurrence and relapse, cancer invasion and metastasis, and cancer immune evasion …

The Wnt/β-catenin signalling pathway plays essential roles in embryonic development and
adult tissue homeostasis, and deregulation of this pathway has been linked to cancer. Axin …