Post‐transcriptional regulation of messenger RNAs (mRNAs)(ie, mechanisms that control
translation, stability and localization) is a critical focal point in spatiotemporal regulation of …

The central role of eukaryotic translation initiation factor 4E (eIF4E) in controlling mRNA
translation has been clearly assessed in the last decades. eIF4E function is essential for …

Full-grown oocytes are transcriptionally silent and must stably maintain the messenger
RNAs (mRNAs) needed for oocyte meiotic maturation and early embryonic development …

Maternal mRNAs are essential for protein synthesis during oogenesis and early
embryogenesis. To adapt translation to specific needs during development, maternal …

Post-transcriptional mechanisms are fundamental safeguards of progenitor cell identity and
are often dysregulated in cancer. Here, we identified regulators of P-bodies as crucial …

The 5′-terminal cap is a fundamental determinant of eukaryotic gene expression which
facilitates cap-dependent translation and protects mRNAs from exonucleolytic degradation …

Current models of mRNA turnover indicate that cytoplasmic degradation is coupled with
translation. However, our understanding of the molecular events that coordinate ribosome …

Pumilio paralogs, PUM1 and PUM2, are sequence-specific RNA-binding proteins that are
essential for vertebrate development and neurological functions. PUM1&2 negatively …

Background Regulation of protein output at the level of translation allows for a rapid
adaptation to dynamic changes to the cell's requirements. This precise control of gene …

Deadenylation‐dependent mRNA decapping and decay is the major cytoplasmic mRNA
turnover pathway in eukaryotes. Many mRNA decapping and decay factors are associated …