As early and effective antiretroviral therapy has become more widespread, HIV has
transitioned from a progressive, fatal disease to a chronic, manageable disease marked by …

Although antiretroviral therapy effectively controls human immunodeficiency virus (HIV)
replication, a residual chronic immune activation/inflammation persists throughout the …

Targeted HIV cure strategies require definition of the mechanisms that maintain the virus.
Here, we tracked HIV replication and the persistence of infected CD4 T cells in individuals …

Untreated HIV-1 infection typically progresses to AIDS within 10 years, but less than 1% of
infected individuals remain healthy and have normal CD4+ T cell counts and undetectable …

Natural regulatory T cells (Tregs) participate in responses to various chronic infections
including HIV. HIV infection is associated with a progressive CD4 lymphopenia and …

Abstract Th17-polarized CD4+ effector T-cells together with their immunosuppressive
regulatory T-cell (Treg) counterparts, with transcriptional profiles governed by the lineage …

Objectives: Glucose metabolism plays a fundamental role in supporting the growth,
proliferation and effector functions of T cells. We investigated the impact of HIV infection on …

Background. Elite controllers spontaneously suppress human immunodeficiency virus (HIV)
viremia but also demonstrate chronic inflammation that may increase risk of comorbid …

Human immunodeficiency virus type 1 (HIV-1) disease is pandemic, with approximately 36
million infected individuals world-wide. For the vast majority of these individuals, untreated …

Activation of the immune system occurs in response to the recognition of foreign antigens
and receipt of optimal stimulatory signals by immune cells, a process that requires energy …