The DNA repair protein, O6-methylguanine DNA methyltransferase (MGMT), can confer
resistance to guanine O6-alkylating agents. Therefore, inhibition of resistant MGMT protein …

Pancreatic cancer (PC) is a highly lethal disease and notoriously difficult to treat. Only a
small proportion of PC patients are eligible for surgical resection, whilst conventional …

Beta-thalassemia and sickle cell anemia are two of the most common diseases related to the
hemoglobin protein. In these diseases, the beta-globin gene is mutated, causing severe …

Background Hematologic toxicity represents a major side effect of cytotoxic chemotherapy
frequently preventing adequately dosed chemotherapy application and impeding …

Abstract O 6-Methylguanine-DNA methyltransferase (MGMT) is a suicide enzyme that
repairs the cytotoxic DNA adducts O 6-methylguanine and O 6-chloroethylguanine induced …

Patients with actively replicating human immunodeficiency virus (HIV) exhibit adverse
reactions even to low irradiation doses. High levels of the virus-encoded viral protein R (Vpr) …

Introduction In neoadjuvant therapy, irradiation has a deleterious effect on neoangiogenesis.
The aim of this study was to examine the post-implantation effects of neoadjuvant irradiation …

Pancreatic cancers are some of the most life-threatening malignancies plaguing the human
race. The aggressiveness of the tumors, inherent genetic resistance to tumors, and late …

Introduction Healing of airway anastomoses after preoperative irradiation can be a
significant clinical problem. The augmentation of bronchial anastomoses with a fibroblast …

Beta-thalassemia is one of the most common diseases related to the hemoglobin protein. In
this disease, the beta-globin gene is mutated, causing severe anemia and ineffective …