As the world population rises, osteoporotic fracture is an emerging global threat to the well-
being of elderly patients. The process of fracture healing by intramembranous ossification …

This systematic review and meta-analysis of randomized controlled trials (RCTs) identified
significant effects of whole body vibration (WBV) on bone mineral density (BMD) of the …

This study is a prospective cluster-randomized controlled clinical trial involving 710 elderly
subjects to investigate the long-term effects of low-magnitude high-frequency vibration …

Low intensity pulsed ultrasound (LIPUS) has been proven effective in promoting fracture
healing but the underlying mechanisms are not fully depicted. We examined the effect of …

Background Pulsed electromagnetic field (PEMF) is reported to be an effective adjunct for
the management of nonunion long-bone fractures. Most studies implement PEMF treatment …

Fracture healing is impaired in aged and osteoporotic individuals. Because adequate
mechanical stimuli are able to increase bone formation, one therapeutical approach to treat …

Sclerostin is a negative regulator of bone formation. Sclerostin monoclonal antibody (Scl‐
Ab) treatment promoted bone healing in various animal models. To further evaluate the …

Mesenchymal stem cells (MSCs) are a promising cell resource for tissue engineering. Sry‐
related high‐mobility group box 11 (Sox11) plays critical roles in neural development and …

Physical exercise benefits breast cancer patients by reducing cancer progression and
promoting bone health. However, intense exercise is physically challenging for bedridden …

Low‐magnitude high‐frequency vibration (LMHFV)(35 Hz, 0.3 g) accelerates fracture
healing by enhancing callus formation and mineralization for both normal and osteoporotic …