ER stress in obesity pathogenesis and management

A Ajoolabady, S Liu, DJ Klionsky, GYH Lip… - Trends in …, 2022 - cell.com
Given the unprecedented global pandemic of obesity, a better understanding of the etiology
of adiposity will be necessary to ensure effective management of obesity and related …

Harnessing amphiphilic polymeric micelles for diagnostic and therapeutic applications: Breakthroughs and bottlenecks

J Kaur, V Mishra, SK Singh, M Gulati, B Kapoor… - Journal of Controlled …, 2021 - Elsevier
Amphiphilic block copolymers are widely utilized in the design of formulations owing to their
unique physicochemical properties, flexible structures and functional chemistry. Amphiphilic …

[HTML][HTML] Anti-hyperglycemic and insulin sensitizer effects of turmeric and its principle constituent curcumin

Z Ghorbani, A Hekmatdoost… - International journal of …, 2014 - ncbi.nlm.nih.gov
Results: Curcumin can reduce blood glucose level by reducing the hepatic glucose
production, suppression of hyperglycemia-induced inflammatory state, stimulation of …

Effect of curcumin supplementation on physiological fatigue and physical performance in mice

WC Huang, WC Chiu, HL Chuang, DW Tang, ZM Lee… - Nutrients, 2015 - mdpi.com
Curcumin (CCM) is a well-known phytocompound and food component found in the spice
turmeric and has multifunctional bioactivities. However, few studies have examined its …

ER stress in cardiometabolic diseases: from molecular mechanisms to therapeutics

A Ajoolabady, S Wang, G Kroemer… - Endocrine …, 2021 - academic.oup.com
The endoplasmic reticulum (ER) hosts linear polypeptides and fosters natural folding of
proteins through ER-residing chaperones and enzymes. Failure of the ER to align and …

Advances in designing of polymeric micelles for biomedical application in brain related diseases

J Kaur, M Gulati, B Kapoor, NK Jha, PK Gupta… - Chemico-Biological …, 2022 - Elsevier
In recent years, unique physicochemical properties of amphiphilic block copolymers have
been utilized to design the polymeric micelles for brain-specific delivery of drugs, proteins …

Protective effect of vanillic acid against hyperinsulinemia, hyperglycemia and hyperlipidemia via alleviating hepatic insulin resistance and inflammation in high-fat diet …

WC Chang, JSB Wu, CW Chen, PL Kuo, HM Chien… - Nutrients, 2015 - mdpi.com
Excess free fatty acid accumulation from abnormal lipid metabolism results in the insulin
resistance in peripheral cells, subsequently causing hyperinsulinemia, hyperglycemia …

Therapeutic effects of curcumin derivatives against obesity and associated metabolic complications: a review of in vitro and in vivo studies

MT Moetlediwa, R Ramashia, C Pheiffer… - International Journal of …, 2023 - mdpi.com
Obesity is a major cause of morbidity and mortality globally, increasing the risk for chronic
diseases. Thus, the need to identify more effective anti-obesity agents has spurred …

Curcumin and insulin resistance—molecular targets and clinical evidences

AS Jiménez‐Osorio, A Monroy, S Alavez - Biofactors, 2016 - Wiley Online Library
Abstract Curcumin ((1E, 6E)− 1, 7‐bis (4‐hydroxy‐3‐methoxyphenyl)‐1, 6‐heptadiene‐3, 5‐
dione), the main component of the Indian spice turmeric, has been used in traditional …

Is there a role for curcumin supplementation in the treatment of non-alcoholic fatty liver disease? The data suggest yes

N Amel Zabihi, M Pirro, TP Johnston… - Current …, 2017 - ingentaconnect.com
Nonalcoholic fatty liver disease (NAFLD) is the most common type of liver disease. NAFLD is
considered a multifactorial disease and a clinically relevant hepatic manifestation of …