Molecular mechanisms of MmuPV1 E6 and E7 and implications for human disease

JC Romero-Masters, PF Lambert, K Munger - Viruses, 2022 - mdpi.com
Human papillomaviruses (HPVs) cause a substantial amount of human disease from benign
disease such as warts to malignant cancers including cervical carcinoma, head and neck …

[HTML][HTML] Small DNA tumor viruses and human cancer: Preclinical models of virus infection and disease

ME Spurgeon - Tumour Virus Research, 2022 - Elsevier
Human tumor viruses cause various human cancers that account for at least 15% of the
global cancer burden. Among the currently identified human tumor viruses, two are small …

Monitoring mouse papillomavirus-associated cancer development using longitudinal Pap smear screening

HM Atkins, AA Uslu, JJ Li, DA Shearer, SA Brendle… - Mbio, 2024 - journals.asm.org
ABSTRACT A substantial percentage of the population remains at risk for cervical cancer
due to pre-existing human papillomavirus (HPV) infections, despite prophylactic vaccines …

Anal cancer prevention: A field in need of scientific Advancement

E Carchman, CB Sanger - Virology, 2024 - Elsevier
Despite the availability of several human papillomavirus (HPV) vaccines, the incidence of
HPV-associated anal cancer is growing at a rate of 2.2% each year. As shown in results from …

MmuPV1 E7's interaction with PTPN14 delays Epithelial differentiation and contributes to virus-induced skin disease

JC Romero-Masters, M Grace, D Lee, J Lei… - PLoS …, 2023 - journals.plos.org
Human papillomaviruses (HPVs) contribute to approximately 5% of all human cancers.
Species-specific barriers limit the ability to study HPV pathogenesis in animal models …

A Novel In Vivo Model of Laryngeal Papillomavirus-Associated Disease Using Mus musculus Papillomavirus

RE King, A Bilger, J Rademacher, ET Ward-Shaw… - Viruses, 2022 - mdpi.com
Recurrent respiratory papillomatosis (RRP), caused by laryngeal infection with low-risk
human papillomaviruses, has devastating effects on vocal communication and quality of life …

Key aspects of papillomavirus infection influence the host cervicovaginal microbiome in a preclinical murine papillomavirus (MmuPV1) infection model

ME Spurgeon, EC Townsend, S Blaine-Sauer… - Mbio, 2024 - Am Soc Microbiol
Human papillomaviruses (HPVs) are the most common sexually transmitted infection in the
United States and are a major etiological agent of cancers in the anogenital tract and oral …

Deficiency in Ever2 does not increase susceptibility of mice to pathogenesis by the mouse papillomavirus, MmuPV1

AD Torres, RE King, A Uberoi, D Buehler… - Journal of …, 2024 - Am Soc Microbiol
Epidermodysplasia verruciformis (EV) is a rare genetic skin disorder that is characterized by
the development of papillomavirus-induced skin lesions that can progress to squamous cell …

MmuPV1 E6 induces cell proliferation and other hallmarks of cancer

JC Romero-Masters, LK Muehlbauer, M Hayes… - Mbio, 2023 - Am Soc Microbiol
The E6 protein encoded by the murine papillomavirus (MmuPV1) is essential for MmuPV1-
induced skin disease. Our previous work has identified a number of cellular interacting …

Efficacy of topically administered dihydroartemisinin in treating papillomavirus-induced anogenital dysplasia in preclinical mouse models

LC Gunder, S Blaine-Sauer, HR Johnson, MK Shin… - Viruses, 2022 - mdpi.com
The artemisinin family of compounds is cytopathic in certain cancer cell lines that are
positive for human papillomaviruses (HPV) and can potentially drive the regression of …