Virtually all adults with Down syndrome (DS) show the neuropathological changes of
Alzheimer disease (AD) by the age of 40 years. This association is partially due to …

Neuroinflammation is proposed as one of the mechanisms by which Alzheimer's disease
pathology, including amyloid-β plaques, leads to neuronal death and dysfunction. Increases …

Alzheimer's disease (AD) is characterized by non-linear, genetic-driven pathophysiological
dynamics with high heterogeneity in biological alterations and disease spatial-temporal …

There are currently no validated biomarkers which can be used to accurately diagnose
Alzheimer's disease (AD) or to distinguish it from other dementia-causing neuropathologies …

Alzheimer's disease (AD) is a neurodegenerative disease with unknown pathogenesis and
complex pathological manifestations. At present, a large number of studies on targeted …

We quantified genome-wide patterns of lysine H3K27 acetylation (H3K27ac) in entorhinal
cortex samples from Alzheimer's disease (AD) cases and matched controls using chromatin …

Neurodegenerative diseases are hereditary or sporadic conditions that result in the
progressive loss of the structure and function of neurons as well as neuronal death …

Phosphoinositide 3-kinase (PI3K) signaling contributes to a variety of processes, mediating
many aspects of cellular function, including nutrient uptake, anabolic reactions, cell growth …

DNA damage is correlated with and may drive the ageing process. Neurons in the brain are
postmitotic and are excluded from many forms of DNA repair; therefore, neurons are …

Mitochondria are important for providing cellular energy ATP through the oxidative
phosphorylation pathway. They are also critical in regulating many cellular functions …