In recent years, our understanding of protein structure and function has advanced rapidly,
providing a mechanistic understanding of a wide variety of biological processes. As an …

ABSTRACT A common focus among molecular and cellular biologists is the identification of
proteins that interact with each other. Yeast two‐hybrid, cDNA expression library screening …

This is a sequel to the previous Perspective “The CH–π hydrogen bond in chemistry.
Conformation, supramolecules, optical resolution and interactions involving carbohydrates” …

Proline residues have unique roles in protein folding, structure, and function. Proline and the
aromatic amino acids comprise the encoded cyclic protein residues. Aromatic protein side …

Proline cis− trans isomerization plays a key role in the rate-determining steps of protein
folding. The energetic origin of this isomerization process is summarized, and the folding …

A large number of macrocyclic miniproteins with diverse biological activities have been
isolated from the Rubiaceae, Violaceae, and Cucurbitaceae plant families in recent years …

Functionalized proline residues have diverse applications. Herein we describe a practical
approach, proline editing, for the synthesis of peptides with stereospecifically modified …

Although hydrophobic interaction is the main contributing factor to the stability of the protein
fold, the specificity of the folding process depends on many directional interactions. An …

The accurate determination of a large number of protein structures by X-ray crystallography
makes it possible to conduct a reliable statistical analysis of the distribution of the main …

Galectin-3 (Gal-3) has a long, aperiodic, and dynamic proline-rich N-terminal tail (NT). The
functional role of the NT with its numerous prolines has remained enigmatic since its …