Subchondral bone osteoclasts induce sensory innervation and osteoarthritis pain

S Zhu, J Zhu, G Zhen, Y Hu, S An, Y Li… - The Journal of …, 2019 - Am Soc Clin Investig
Joint pain is the defining symptom of osteoarthritis (OA) but its origin and mechanisms
remain unclear. Here, we investigated an unprecedented role of osteoclast-initiated …

Sensory involvement in amyotrophic lateral sclerosis

MA Rubio, M Herrando-Grabulosa… - International journal of …, 2022 - mdpi.com
Although amyotrophic lateral sclerosis (ALS) is pre-eminently a motor disease, the existence
of non-motor manifestations, including sensory involvement, has been described in the last …

Connectomic analysis of brain networks: novel techniques and future directions

JL Cazemier, F Clascá, PHE Tiesinga - Frontiers in neuroanatomy, 2016 - frontiersin.org
Brain networks, localized or brain-wide, exist only at the cellular level, ie, between specific
pre-and post-synaptic neurons, which are connected through functionally diverse synapses …

Targeted multiple reaction monitoring analysis of CSF identifies UCHL1 and GPNMB as candidate biomarkers for ALS

S Zhu, A Wuolikainen, J Wu, A Öhman… - Journal of Molecular …, 2019 - Springer
The neurodegenerative diseases amyotrophic lateral sclerosis (ALS) and Parkinson's
disease (PD) share some common molecular deficits including disruption of protein …

The engineered AAV2-HBKO promotes non-invasive gene delivery to large brain regions beyond ultrasound targeted sites

RH Kofoed, K Noseworthy, K Wu, S Sivadas… - … Therapy-Methods & …, 2022 - cell.com
Magnetic resonance imaging-guided focused ultrasound combined with microbubbles
injected in the bloodstream (MRIgFUS) temporarily increases the permeability of the blood …

Characterization of somatosensory neuron involvement in the SOD1G93A mouse model

MA Rubio, M Herrando-Grabulosa… - Scientific Reports, 2022 - nature.com
Abstract SOD1G93A mice show loss of cutaneous small fibers, as in ALS patients. Our
objective is to characterize the involvement of different somatosensory neuron populations …

Neural differentiation of human adipose‐derived mesenchymal stem cells induced by glial cell conditioned media

D Lo Furno, G Mannino, R Giuffrida… - Journal of Cellular …, 2018 - Wiley Online Library
Adipose‐derived mesenchymal stem cells (ASCs) may transdifferentiate into cells belonging
to mesodermal, endodermal, and ectodermal lineages. The aim of this study was to verify …

Diabetic sensory neuropathy and insulin resistance are induced by loss of UCHL1 in Drosophila

D Lee, E Yoon, SJ Ham, K Lee, H Jang, D Woo… - Nature …, 2024 - nature.com
Diabetic sensory neuropathy (DSN) is one of the most common complications of type 2
diabetes (T2D), however the molecular mechanistic association between T2D and DSN …

Modeling mammalian spermatogonial differentiation and meiotic initiation in vitro

O Kirsanov, T Johnson, T Malachowski… - …, 2022 - journals.biologists.com
In mammalian testes, premeiotic spermatogonia respond to retinoic acid by completing an
essential lengthy differentiation program before initiating meiosis. The molecular and …

Involvement of sensory innervation in the skin of SOD1G93A ALS mice

MA Rubio, M Herrando‐Grabulosa… - Journal of the …, 2016 - Wiley Online Library
Sensory alterations have been described in both amyotrophic lateral sclerosis (ALS)
patients and mouse models. While involvement of intraepidermal and subepidermal axons …