[HTML][HTML] Oxidative stress in aging-matters of the heart and mind
K Venkataraman, S Khurana, TC Tai - International journal of molecular …, 2013 - mdpi.com
Oxidative damage is considered to be the primary cause of several aging associated
disease pathologies. Cumulative oxidative damage tends to be pervasive among cellular …
disease pathologies. Cumulative oxidative damage tends to be pervasive among cellular …
Role of matrix metalloproteinases in the pathogenesis of traumatic brain injury
PM Abdul-Muneer, BJ Pfister, J Haorah… - Molecular …, 2016 - Springer
Traumatic brain injury (TBI) is a major cause of mortality and morbidity worldwide. Studies
revealed that the pathogenesis of TBI involves upregulation of MMPs. MMPs form a large …
revealed that the pathogenesis of TBI involves upregulation of MMPs. MMPs form a large …
Impairment of pericyte-endothelium crosstalk leads to blood-brain barrier dysfunction following traumatic brain injury
The blood-brain barrier (BBB) constitutes a neurovascular unit formed by microvascular
endothelial cells, pericytes, and astrocytes. Brain pericytes are important regulators of BBB …
endothelial cells, pericytes, and astrocytes. Brain pericytes are important regulators of BBB …
Induction of oxidative and nitrosative damage leads to cerebrovascular inflammation in an animal model of mild traumatic brain injury induced by primary blast
PM Abdul-Muneer, H Schuetz, F Wang… - Free Radical Biology …, 2013 - Elsevier
We investigate the hypothesis that oxidative damage of the cerebral vascular barrier
interface (the blood–brain barrier, BBB) causes the development of mild traumatic brain …
interface (the blood–brain barrier, BBB) causes the development of mild traumatic brain …
Primary blast causes mild, moderate, severe and lethal TBI with increasing blast overpressures: Experimental rat injury model
Injury severity in blast induced Traumatic Brain Injury (bTBI) increases with blast
overpressure (BOP) and impulse in dose-dependent manner. Pure primary blast waves …
overpressure (BOP) and impulse in dose-dependent manner. Pure primary blast waves …
Increased expression of M1 and M2 phenotypic markers in isolated microglia after four-day binge alcohol exposure in male rats
Microglia activation and neuroinflammation are common features of neurodegenerative
conditions, including alcohol use disorders (AUDs). When activated, microglia span a …
conditions, including alcohol use disorders (AUDs). When activated, microglia span a …
Mitocytosis Mediated by an Enzyme‐Activable Mitochondrion‐Disturbing Polymer‐Drug Conjugate Enhances Active Penetration in Glioblastoma Therapy
The application of nanomedicines for glioblastoma (GBM) therapy is hampered by the blood–
brain barrier (BBB) and the dense glioblastoma tissue. To achieve efficient BBB crossing …
brain barrier (BBB) and the dense glioblastoma tissue. To achieve efficient BBB crossing …
Innate immune activation: Parallels in alcohol use disorder and Alzheimer's disease
Alcohol use disorder is associated with systemic inflammation and organ dysfunction
especially in the liver and the brain. For more than a decade, studies have highlighted …
especially in the liver and the brain. For more than a decade, studies have highlighted …
Role of microglia in ethanol-induced neurodegenerative disease: Pathological and behavioral dysfunction at different developmental stages
JY Yang, X Xue, H Tian, XX Wang, YX Dong… - Pharmacology & …, 2014 - Elsevier
Alcohol abuse can result in significant alterations to the structure of the brain and ultimately
to behavioral dysfunctions. Epidemiological studies have shown that alcoholism is closely …
to behavioral dysfunctions. Epidemiological studies have shown that alcoholism is closely …
The mechanisms of cerebral vascular dysfunction and neuroinflammation by MMP-mediated degradation of VEGFR-2 in alcohol ingestion
PMA Muneer, S Alikunju, AM Szlachetka… - … , and vascular biology, 2012 - Am Heart Assoc
Objective—Blood-brain barrier (BBB) dysfunction caused by activation of matrix
metalloproteinases (MMPs) is a pathological feature in vascular/neurological disease. We …
metalloproteinases (MMPs) is a pathological feature in vascular/neurological disease. We …