Blood GFAP as an emerging biomarker in brain and spinal cord disorders
Blood-derived biomarkers for brain and spinal cord diseases are urgently needed. The
introduction of highly sensitive immunoassays led to a rapid increase in the number of …
introduction of highly sensitive immunoassays led to a rapid increase in the number of …
The inter-relationship between delirium and dementia: the importance of delirium prevention
Delirium and dementia are two frequent causes of cognitive impairment among older adults
and have a distinct, complex and interconnected relationship. Delirium is an acute …
and have a distinct, complex and interconnected relationship. Delirium is an acute …
Comparison of serum neurodegenerative biomarkers among hospitalized COVID‐19 patients versus non‐COVID subjects with normal cognition, mild cognitive …
JA Frontera, A Boutajangout, AV Masurkar… - Alzheimer's & …, 2022 - Wiley Online Library
Introduction Neurological complications among hospitalized COVID‐19 patients may be
associated with elevated neurodegenerative biomarkers. Methods Among hospitalized …
associated with elevated neurodegenerative biomarkers. Methods Among hospitalized …
[HTML][HTML] Postoperative delirium and changes in the blood–brain barrier, neuroinflammation, and cerebrospinal fluid lactate: a prospective cohort study
Background Case-control studies have associated delirium with blood–brain barrier (BBB)
permeability. However, this approach cannot determine whether delirium is attributable to …
permeability. However, this approach cannot determine whether delirium is attributable to …
The physio-affective phenome of major depression is strongly associated with biomarkers of astroglial and neuronal projection toxicity which in turn are associated …
HK Al-Hakeim, TH Al-Naqeeb, AF Almulla… - Journal of affective …, 2023 - Elsevier
Background Major depressive disorder (MDD) is characterized by elevated activity of
peripheral neuro-immune and neuro-oxidative pathways, which may cause neuro-affective …
peripheral neuro-immune and neuro-oxidative pathways, which may cause neuro-affective …
Preoperative plasma Tau-PT217 and Tau-PT181 are associated with postoperative delirium
Objective: This study aims to identify blood biomarkers of postoperative delirium.
Background: Phosphorylated tau at threonine 217 (Tau-PT217) and 181 (Tau-PT181) are …
Background: Phosphorylated tau at threonine 217 (Tau-PT217) and 181 (Tau-PT181) are …
Neuroinflammation in perioperative neurocognitive disorders: From bench to the bedside
Y Liu, H Fu, T Wang - CNS Neuroscience & Therapeutics, 2022 - Wiley Online Library
The perioperative neurocognitive disorders (PNDs) are one of the most common
complications in elderly patients characterized by various forms of cognitive decline after …
complications in elderly patients characterized by various forms of cognitive decline after …
Effect of general anesthesia with thoracic paravertebral block on postoperative delirium in elderly patients undergoing thoracoscopic lobectomy: a randomized …
W Wei, X Zheng, Y Gu, W Fu, C Tang, Y Yao - BMC anesthesiology, 2022 - Springer
Background Postoperative delirium (POD) is characterized by acute brain dysfunction,
especially in elderly patients. Postoperative pain is an important factor in the development of …
especially in elderly patients. Postoperative pain is an important factor in the development of …
Mitigation of perioperative neurocognitive disorders: A holistic approach
William Morton introduced the world to ether anesthesia for use during surgery in the
Bullfinch Building of the Massachusetts General Hospital on October 16, 1846. For nearly …
Bullfinch Building of the Massachusetts General Hospital on October 16, 1846. For nearly …
Postoperative changes in cognition and cerebrospinal fluid neurodegenerative disease biomarkers
M Berger, JN Browndyke… - Annals of clinical …, 2022 - Wiley Online Library
Objective Numerous investigators have theorized that postoperative changes in Alzheimer's
disease neuropathology may underlie postoperative neurocognitive disorders. Thus, we …
disease neuropathology may underlie postoperative neurocognitive disorders. Thus, we …