p53 is a nuclear transcription factor with a pro-apoptotic function. Since over 50% of human
cancers carry loss of function mutations in p53 gene, p53 has been considered to be one of …

Interest in the tumour suppressor p53 has generated much information regarding the
complexity of its function and regulation in carcinogenesis. However, gaps still exist in our …

p53 plays a key role in mediating cell response to various stresses, mainly by inducing or
repressing a number of genes involved in cell cycle arrest, senescence, apoptosis, DNA …

Defining the genes that are essential for cellular proliferation is critical for understanding
organismal development and identifying high-value targets for disease therapies. However …

Hepatocellular carcinoma (HCC) is one of the most frequent tumors worldwide with rising
incidence. The inflammatory cytokine, interleukin‐6 (IL‐6), is a critical mediator of HCC …

DNA fragmentation is a hallmark of apoptosis that is induced by apoptotic stimuli in various
cell types. Apoptotic signal pathways, which eventually cause DNA fragmentation, are …

Cells are constantly suffering genotoxic stresses that affect the integrity of our genetic
material. Genotoxic insults must be repaired to avoid the loss or inappropriate transmission …

p53 is one of the most studied tumor suppressors in the cancer research field. Of note, over
50% of human tumors carry loss of function mutations, and thus p53 has been considered to …

Maintenance of genome integrity is fundamental for cellular physiology. Our hereditary
information encoded in the DNA is intrinsically susceptible to suffer variations, mostly due to …

A block in apoptotic cell death is a likely requirement for cancer maintenance. Likewise, drug
resistance, one of the key clinical problems in oncology, can often be explained by apoptotic …