Sulfur fluoride exchange

JA Homer, L Xu, N Kayambu, Q Zheng… - Nature Reviews …, 2023 - nature.com
Click chemistry is a conceptual strategy to rapidly synthesize and discover functional
molecules. Sulfur fluoride exchange (SuFEx) is a click reaction that has revolutionized …

Linkage chemistry of S (VI) fluorides

D Zeng, WP Deng, X Jiang - Chemistry–A European Journal, 2023 - Wiley Online Library
Sulfur (VI)‐fluoride exchange linkage as a next generation of click chemistry was introduced
by Sharpless and coworkers in 2014. Distinguished from CuAAC, the SuFEx reaction …

Direct Fluorosulfonamidation of (Hetero) arenes and Alkenes with Photoredox-Active Fluorosulfamoyl Radical Reagents

T Xiong, QL Chen, ZY Zhang, G Lu, J Weng - ACS Catalysis, 2024 - ACS Publications
Sulfur (VI) fluoride exchange (SuFEx) is a second-generation click chemistry reaction that
relies on the unique reactivities of SVI–F bonds. The development of efficient methods for …

Stereospecific reaction of sulfonimidoyl fluorides with Grignard reagents for the synthesis of enantioenriched sulfoximines

S Greed, O Symes, JA Bull - Chemical Communications, 2022 - pubs.rsc.org
Sulfonimidoyl halides have previously shown poor stability and selectivity in reaction with
organometallic reagents. Here we report the preparation of enantioenriched sulfonimidoyl …

Recent Advances of S–18F Radiochemistry for Positron Emission Tomography

X Deng, X Zhu - ACS omega, 2023 - ACS Publications
The click chemistry of sulfur (VI) fluoride exchange (SuFEx) has facilitated the widespread
application of sulfur–fluoride compounds such as sulfonyl fluorides, fluorosulfates, and …

Arene radiofluorination enabled by photoredox-mediated halide interconversion

W Chen, H Wang, NES Tay, VA Pistritto, KP Li… - Nature …, 2022 - nature.com
Positron emission tomography (PET) is a powerful imaging technology that can visualize
and measure metabolic processes in vivo and/or obtain unique information about drug …

Study of Carbamoyl Fluoride: Synthesis, Properties and Applications

C Bonnefoy, E Chefdeville, C Tourvieille… - … A European Journal, 2022 - Wiley Online Library
Carbamoyl fluoride is a fluorinated group that, to this date, remains underexplored, probably
due to the lack of data concerning its properties. In this paper, a study of carbamoyl fluoride …

Preparation of 18F-Labeled Tracers Targeting Fibroblast Activation Protein via Sulfur [18F]Fluoride Exchange Reaction

A Craig, J Kogler, M Laube, M Ullrich, CK Donat… - Pharmaceutics, 2023 - mdpi.com
Early detection and treatment of cancers can significantly increase patient prognosis and
enhance the quality of life of affected patients. The emerging significance of the tumor …

Desmethyl SuFEx-IT: SO2F2-Free Synthesis and Evaluation as a Fluorosulfurylating Agent

J Bertram, F Neumaier, BD Zlatopolskiy… - The Journal of …, 2024 - ACS Publications
Access to SuFExable compounds was remarkably simplified by introduction of the solid
FO2S-donor SuFEx-IT. However, the published process for preparation of this reagent relies …

Isotope Exchange-Based 18F-Labeling Methods

T Wang, S Lv, Z Mou, Z Zhang, T Dong… - Bioconjugate …, 2023 - ACS Publications
18F-Labeling methods for the preparation of 18F-labeled molecular probes can be classified
into electrophilic fluorination, nucleophilic fluorination, metal-F coordination, and 18F/19F …