G-protein-coupled receptors (GPCRs) have been tractable drug targets for decades with
over one-third of currently marketed drugs targeting GPCRs. Of these, the class A GPCR …

Allosteric modulation is a direct and effective method for regulating the function of biological
macromolecules, which play vital roles in various cellular activities. Unlike orthosteric …

INTRODUCTION The mammalian nose is arguably the best chemical sensor on the planet,
able to detect and discriminate among a large and diverse repertoire of mostly small …

The serotonin 5-HT2A receptor (5-HT2AR) and 5-HT2CR localize to the brain and share
overlapping signal transduction facets that contribute to their roles in cognition, mood …

Odor perception is first determined by how the myriad of environmental volatiles are
detected at the periphery of the olfactory system. The combinatorial activation of dedicated …

Serotonin (5-HT) 5-HT2C receptor (5-HT2CR) is recognized as a critical mediator of
diseaserelated pathways and behaviors based upon actions in the central nervous system …

Substance use disorder (SUD) is a chronic condition, with maintained abuse of a substance
leading to physiological and psychological alterations and often changes in cognitive and …

Schizophrenia was first described by Emil Krapelin in the 19th century as one of the major
mental illnesses causing disability worldwide. Since the introduction of chlorpromazine in …

The olfactory world is one of complex mixtures and blends containing up to hundreds of
molecules. Many of those molecules can act as agonists, antagonists or enhancers at …

Gastrointestinal motility is tightly regulated by the enteric nervous system (ENS). Disruption
of coordinated enteric nervous system activity can result in dysmotility. Pharmacological …