The mesolimbic hypothesis has been a central dogma of schizophrenia for decades,
positing that aberrant functioning of midbrain dopamine projections to limbic regions causes …

The striatum is essential for learning which actions lead to reward and for implementing
those actions. Decades of experimental and theoretical work have led to several influential …

Substance use disorder (SUD) is a chronic, relapsing disease with a highly multifaceted
pathology that includes (but is not limited to) sensitivity to drug-associated cues, negative …

How does cognition regulate innate behaviors? While the cognitive functions of the cortex
have been extensively studied, we know much less about how cognition can regulate innate …

The cortex projects to the dorsal striatum topographically, to regulate behaviour,–, but
spiking activity in the two structures has previously been reported to have markedly different …

The striatal and pallidal complexes are basal ganglia structures that orchestrate learning
and execution of flexible behavior. Models of how the basal ganglia subserve these …

Here, we review the neural circuit bases of habits, compulsions, and addictions, behaviors
which are all characterized by relatively automatic action performance. We discuss relevant …

Optogenetic stimulation of Adora2a receptor-expressing spiny projection neurons (A2A-
SPNs) in the striatum drives locomotor suppression and transient punishment, results …

Substantia nigra dopamine neurons have been implicated in the initiation and invigoration
of movement, presumably through their modulation of striatal projection neuron (SPN) …

The last two decades have witnessed substantial advances in identifying synaptic plasticity
responsible for behavioral changes in animal models of substance use disorder. We have …