Delivery systems for mitochondrial gene therapy: a review

R Faria, P Boisguérin, Â Sousa, D Costa - Pharmaceutics, 2023 - mdpi.com
Mitochondria are membrane-bound cellular organelles of high relevance responsible for the
chemical energy production used in most of the biochemical reactions of cells. Mitochondria …

[HTML][HTML] Mitochondrial DNA-targeted therapy: A novel approach to combat cancer

Y Lin, B Yang, Y Huang, Y Zhang, Y Jiang, L Ma… - Cell Insight, 2023 - Elsevier
Mitochondrial DNA (mtDNA) encodes proteins and RNAs that are essential for mitochondrial
function and cellular homeostasis, and participates in important processes of cellular …

A switch in N-terminal capping of β-peptides creates novel self-assembled nanoparticles

YK Chen, IA Simon, I Maslov, IE Oyarce-Pino… - RSC …, 2023 - pubs.rsc.org
Small tripeptides composed entirely of β3-amino acids have been shown to self-assemble
into fibres following acylation of the N-terminus. Given the use of Fmoc as a strategy to …

Emerging landscape of cell-penetrating peptide-mediated organelle restoration and replacement

J Geng, J Wang, H Wang - ACS Pharmacology & Translational …, 2023 - ACS Publications
Organelles are specialized subunits within a cell membrane that perform specific roles or
functions, and their dysfunction can lead to a variety of pathophysiologies including …

Evidence That a Peptide-Drug/p53 Gene Complex Promotes Cognate Gene Expression and Inhibits the Viability of Glioblastoma Cells

A Neves, T Albuquerque, R Faria, CRA Santos, E Vivès… - Pharmaceutics, 2024 - mdpi.com
Glioblastoma multiform (GBM) is considered the deadliest brain cancer. Conventional
therapies are followed by poor patient survival outcomes, so novel and more efficacious …

[HTML][HTML] Upgrading Mitochondria-Targeting Peptide-Based Nanocomplexes for Zebrafish In Vivo Compatibility Assays

R Faria, E Vivès, P Boisguérin, S Descamps, Â Sousa… - Pharmaceutics, 2024 - mdpi.com
The lack of effective delivery systems has slowed the development of mitochondrial gene
therapy. Delivery systems based on cell-penetrating peptides (CPPs) like the WRAP …

Optimization of Dendritic Polypeptide Delivery System for Antisense Antibacterial Agents Targeting ftsZ

Y Li, Y Hu, Z Kamal, Y Chen, X Xue, S Yao, H Zhao… - ACS …, 2024 - ACS Publications
There is an urgent requirement for a novel treatment strategy for drug-resistant
Staphylococcus aureus (S. aureus) infection. Antisense antimicrobials are promising …

«New Modalities in Cancer Imaging and Therapy» XVe édition de l'atelier organisé par le réseau «Vectorisation, Imagerie, Radiothérapies» du Cancéropôle Grand …

F Léost, J Barbet, M Beyler, M Chérel, G Delpon… - Bulletin du …, 2023 - Elsevier
Résumé La quinzième édition de l'atelier international organisé par le réseau
«Vectorisation, Imagerie, Radiothérapies» du Cancéropôle Grand-Ouest a porté sur les …

Targeting Specific Barriers

Ü Langel - CPP, Cell-Penetrating Peptides, 2023 - Springer
Targeting Specific Barriers | SpringerLink Skip to main content Advertisement SpringerLink
Account Menu Find a journal Publish with us Track your research Search Cart Book cover …

[PDF][PDF] Desenvolvimento de vetores baseados em péptidos para direcionamento à mitocôndria

SCMD Varela - 2023 - core.ac.uk
As mitocôndrias são organelos citoplasmáticos presentes na maioria das células
eucarióticas sendo responsáveis pela produção de 90% de ATP, moléculas indispensáveis …