Acetylation is one of the major post-translational protein modifications in the cell, with
manifold effects on the protein level as well as on the metabolome level. The acetyl group …

N-terminal acetylation (Nt-acetylation) is a widespread protein modification among
eukaryotes and prokaryotes alike. By appending an acetyl group to the N-terminal amino …

Recent studies of N-terminal acetylation have identified new N-terminal acetyltransferases
(NATs) and expanded the known functions of these enzymes beyond their roles as ribosome …

The majority of eukaryotic proteins are subjected to N-terminal acetylation (Nt-acetylation),
catalysed by N-terminal acetyltransferases (NATs). Recently, the structure of an NAT …

The human N-terminal acetyltransferases (NATs) catalyze the transfer of acetyl moieties to
the N-termini of 80–90% of all human proteins. Six NAT types are present in humans, NatA …

Heat shock protein (Hsp) 70 is a molecular chaperone that maintains protein homoeostasis
during cellular stress through two opposing mechanisms: protein refolding and degradation …

Recent proteomic studies reveal that 5–10% of mammalian and bacterial proteins undergo
lysine acetylation, a post-translational modification that adds an acetyl group to the ɛ-amino …

Recent studies revealed the power of whole-exome sequencing to identify mutations in
sporadic cases with non-syndromic intellectual disability. We now identified de novo …

Introduction Lenz microphthalmia syndrome (LMS) is a genetically heterogeneous X-linked
disorder characterised by microphthalmia/anophthalmia, skeletal abnormalities …

N-terminal acetylation (NTA) is one of the most abundant protein modifications known, and
the N-terminal acetyltransferase (NAT) machinery is conserved throughout all Eukarya. Over …