The reduction in androgen synthesis and the blockade of the androgen receptor (AR)
function by chemical castration and AR signaling inhibitors represent the main treatment …

Abstract FK506 binding protein 52 (FKBP52)(gene name FKBP4) is a 52 kDa protein that
belongs to the FKBP family; it binds to the immunosuppressant FK506 and has proline …

Prostate cancer is initially regulated by the androgen receptor (AR), a ligand-activated,
transcription factor, and is in a hormone-dependent state (hormone-sensitive prostate …

One critical mechanism through which prostate cancer (PCa) adapts to treatments targeting
androgen receptor (AR) signaling is the emergence of ligand-binding domain-truncated and …

Although androgen deprivation therapy (ADT) by the anti-androgen drug enzalutamide
(Enz) may improve the survival level of patients with castration-resistant prostate cancer …

Simple Summary The methyltransferase KMT5A is suggested as an oncogene in prostate
cancer but the mechanisms underlying its oncogenic properties are poorly understood. This …

Simple Summary Castration-resistant prostate cancer (CRPC) resists standard therapies,
partly due to the androgen receptor variant AR-V7. Conventional treatments like …

Methods Male FVB mice implanted with Myc-CaP tumor cells, or male C57BL/6 mice
implanted with TRAMP-C1 prostate tumor cells, were treated with a DNA vaccine encoding …

目的· 研究KH 型剪接调节蛋白(KH-type splicing regulatory protein, KHSRP)
对前列腺癌细胞增殖能力的影响及其下游基因的表达调控, 考察KHSRP 在前列腺癌由雄激素 …

While chromatin alterations are linked to prostate cancer development, the role of histone
demethylases in the development of prostate cancer has not been fully elucidated. Members …