Molecular mechanisms of vascular health: insights from vascular aging and calcification
Cardiovascular disease is the most common cause of death worldwide, especially beyond
the age of 65 years, with the vast majority of morbidity and mortality due to myocardial …
the age of 65 years, with the vast majority of morbidity and mortality due to myocardial …
2023 ESH Guidelines for the management of arterial hypertension The Task Force for the management of arterial hypertension of the European Society of …
G Mancia, R Kreutz, M Brunström, M Burnier… - Journal of …, 2023 - journals.lww.com
Document Reviewers: Luis Alcocer (Mexico), Christina Antza (Greece), Mustafa Arici
(Turkey), Eduardo Barbosa (Brazil), Adel Berbari (Lebanon), Luıs Bronze (Portugal), John …
(Turkey), Eduardo Barbosa (Brazil), Adel Berbari (Lebanon), Luıs Bronze (Portugal), John …
Current state and future of polygenic risk scores in cardiometabolic disease: a scoping review
A polygenic risk score (PRS) is derived from a genome-wide association study and
represents an aggregate of thousands of single-nucleotide polymorphisms that provide a …
represents an aggregate of thousands of single-nucleotide polymorphisms that provide a …
Power of inclusion: Enhancing polygenic prediction with admixed individuals
Y Tanigawa, M Kellis - The American Journal of Human Genetics, 2023 - cell.com
Admixed individuals offer unique opportunities for addressing limited transferability in
polygenic scores (PGSs), given the substantial trans-ancestry genetic correlation in many …
polygenic scores (PGSs), given the substantial trans-ancestry genetic correlation in many …
Cardiovascular disease risk assessment using traditional risk factors and polygenic risk scores in the million veteran program
Importance Primary prevention of atherosclerotic cardiovascular disease (ASCVD) relies on
risk stratification. Genome-wide polygenic risk scores (PRSs) are proposed to improve …
risk stratification. Genome-wide polygenic risk scores (PRSs) are proposed to improve …
Eradicating atherosclerotic events by targeting early subclinical disease: it is time to retire the therapeutic paradigm of too much, too late
KJ Williams - Arteriosclerosis, Thrombosis, and Vascular Biology, 2024 - Am Heart Assoc
Recent decades have seen spectacular advances in understanding and managing
atherosclerotic cardiovascular disease, but paradoxically, clinical progress has stalled …
atherosclerotic cardiovascular disease, but paradoxically, clinical progress has stalled …
Novel polygenic risk score and established clinical risk factors for risk estimation of aortic stenosis
AM Small, GEM Melloni, FK Kamanu… - JAMA …, 2024 - jamanetwork.com
Importance Polygenic risk scores (PRSs) have proven to be as strong as or stronger than
established clinical risk factors for many cardiovascular phenotypes. Whether this is true for …
established clinical risk factors for many cardiovascular phenotypes. Whether this is true for …
Somatic and germline variants and coronary heart disease in a Chinese population
K Zhao, X Shen, H Liu, Z Lin, J Li, S Chen, F Liu… - JAMA …, 2024 - jamanetwork.com
Importance The genetic basis of coronary heart disease (CHD) has expanded from a
germline to somatic genome, including clonal hematopoiesis of indeterminate potential …
germline to somatic genome, including clonal hematopoiesis of indeterminate potential …
Multi-ancestry polygenic risk score for coronary heart disease based on an ancestrally diverse genome-wide association study and population-specific optimization
BACKGROUND: Predictive performance of polygenic risk scores (PRS) varies across
populations. To facilitate equitable clinical use, we developed PRS for coronary heart …
populations. To facilitate equitable clinical use, we developed PRS for coronary heart …
Cardiovascular Pharmacogenetics: From Discovery of Genetic Association to Clinical Adoption of Derived Test
B Delabays, K Trajanoska… - Pharmacological …, 2024 - pharmrev.aspetjournals.org
Recent breakthroughs in human genetics and in information technologies have markedly
expanded our understanding at the molecular level of the response to drugs, ie …
expanded our understanding at the molecular level of the response to drugs, ie …