Systemic administration of the local anaesthetic lidocaine is antinociceptive in both acute
and chronic pain states, especially in acute postoperative and chronic neuropathic pain …

Ion channels are membrane proteins expressed in almost all living cells. The sequencing of
the human genome has identified more than 400 putative ion channels, but only a fraction of …

K+ channels with two-pore domain (K2p) form a large family of hyperpolarizing channels.
They produce background currents that oppose membrane depolarization and cell …

Two-pore-domain potassium (K2P-) channels conduct outward K+ currents that maintain the
resting membrane potential and modulate action potential repolarization. Members of the …

K2P (KCNK) potassium channels generate “leak” potassium currents that strongly influence
cellular excitability and contribute to pain, somatosensation, anesthesia, and mood. Despite …

Mechanotransduction by the trabecular meshwork (TM) is an essential component of
intraocular pressure regulation in the vertebrate eye. This process is compromised in …

Abstract TWIK-related K+ channel (TREK-1) two-pore-domain potassium (K 2P) channels
mediate background potassium currents and regulate cellular excitability in many different …

Glutamatergic and GABAergic synaptic transmission controls excitation and inhibition of
postsynaptic neurons, whereas activity of ion channels modulates neuronal intrinsic …

Effective and safe pharmacological management of cardiac arrhythmia still constitutes a
major clinical challenge. Outward potassium currents mediated by two-pore-domain …

Potassium (K+) channels are membrane proteins expressed in most living cells that
selectively control the flow of K+ ions. More than 80 genes encode the K+ channel subunits …