Live imaging is a powerful tool, enabling scientists to observe living organisms in real time.
In particular, when combined with fluorescence microscopy, live imaging allows the …

By providing spatial, molecular and morphological data over time, live-cell imaging can
provide a deeper understanding of the cellular and signalling events that determine cancer …

Fusion oncoproteins (FOs) arise from chromosomal translocations in~ 17% of cancers and
are often oncogenic drivers. Although some FOs can promote oncogenesis by undergoing …

The mussel byssus stem provides a strong and compact mechanically mismatched
biointerface between living tissue and a nonliving biopolymer. Yet, in a poorly understood …

Across biological systems, cells undergo coordinated changes in gene expression, resulting
in transcriptome dynamics that unfold within a low-dimensional manifold. While low …

Glioblastoma (GBM) tumors consist of multiple cell populations, including self-renewing
glioblastoma stem cells (GSCs) and immunosuppressive microglia. Here we identified …

Reverse transcription has frequently been co-opted for cellular functions and in prokaryotes
is associated with protection against viral infection, but the underlying mechanisms of …

Every collected photon is precious in live-cell super-resolution (SR) microscopy. Here, we
describe a data-efficient, deep learning-based denoising solution to improve diverse SR …

Innate immune pattern recognition receptors, such as the Toll-like receptors (TLRs), are key
mediators of the immune response to infection and central to our understanding of health …

Abstract Three-dimensional (3D) reconstruction of living brain tissue down to an individual
synapse level would create opportunities for decoding the dynamics and structure–function …