Neurofibromatosis type 1 is a relatively common inherited disorder. Patients have a high
predisposition to develop both benign and malignant tumours. Although many …

Abstract Neurofibromatosis type 1 (NF1) is a common genetic disorder that predisposes
affected individuals to tumours. The NF1 gene encodes a RAS GTPase-activating protein …

Importance Neurofibromatosis type 1 (NF1) is a complex genetic disorder that is associated
with not only neurofibromas, but also an increased susceptibility to other neoplasms …

Neuroibromatosis type 1 (NF1) is a multisystem disorder that primarily involves the skin and
peripheral nervous system. Its population prevalence is approximately 1 in 3000. The …

Neurofibromatosis type 1 is a relatively common genetic disease, with a prevalence ranging
between 1/3000 and 1/6000 people worldwide. The disease affects multiple systems with …

Neurofibromatosis 1 (NF1) is a common neurocutaneous condition with an autosomal
dominant pattern of inheritance. The complications are diverse and disease expression …

Aortic aneurysm is common, accounting for 1–2% of all deaths in industrialized countries.
Early theories of the causes of human aneurysm mostly focused on inherited or acquired …

Neurofibromatosis 1 is an autosomal dominant disorder characterized by multiple café-au-
lait spots, axillary and inguinal freckling, multiple cutaneous neurofibromas, and iris Lisch …

Neurofibromatosis type 1 (NF1) is an autosomal dominant condition with a worldwide
incidence of∼ 1 per 2500 to 3000 individuals. Caused by a germ-line–inactivating mutation …

The vascular smooth muscle cell (SMC)-specific isoform of α-actin (ACTA2) is a major
component of the contractile apparatus in SMCs located throughout the arterial system …