Regulated fibroblast growth factor (FGF) signalling is a prerequisite for the correct
development and homeostasis of articular cartilage, as evidenced by the fact that aberrant …

Arthritis affects millions of people worldwide. With only a few disease-modifying drugs
available for treatment of rheumatoid arthritis and none for osteoarthritis, a clear need exists …

Synovial joints comprise several tissue types, including articular cartilage, the capsule, and
ligaments. All of these compartments are commonly assumed to originate from an early set …

Intervertebral disc degeneration describes the vicious cycle of the deterioration of
intervertebral discs and can eventually result in degenerative disc disease (DDD), which is …

Objective We previously found in our embryonic studies that proper regulation of the
chemokine CCL12 through its sole receptor CCR2, is critical for joint and growth plate …

Osteoarthritis (OA) is a common and problematic disorder that is often associated with
chronic pain, a combination that renders OA a leading cause of physical disability and an …

The ideal cell type to be used for cartilage therapy should possess a proven chondrogenic
capacity, not cause donor‐site morbidity, and should be readily expandable in culture …

The joints are a diverse group of skeletal structures, and their genesis, morphogenesis, and
acquisition of specialized tissues have intrigued biologists for decades. Here we review past …

Synovial joint development begins with the formation of the interzone, a region of
condensed mesenchymal cells at the site of the prospective joint. Recently, lineage-tracing …

The synovial cavity and its fluid are essential for joint function and lubrication, but their
developmental biology remains largely obscure. Here, we analyzed E12. 5 to E18. 5 mouse …